In the Drosophila brain, ‘compass’ neurons track the orientation of the body and head (the fly’s
heading) during navigation 1 , 2 . In the absence of visual cues, the compass neuron …

Previously, we identified progressive alterations in spontaneous EPSCs and IPSCs in the
striatum of the R6/2 mouse model of Huntington's disease (HD). Medium-sized spiny neurons …

In neural networks that store information in their connection weights, there is a tradeoff between
sensitivity and stability 1 , 2 . Connections must be plastic to incorporate new information…

In the visual system, peripheral processing circuits are often tuned to specific stimulus features.
How this selectivity arises and how these circuits are organized to inform specific visual …

There is considerable evidence that alterations in striatal medium-sized spiny neurons (MSSNs)
giving rise to the direct (D1 receptor-expressing) and indirect (D2 receptor-expressing) …

Detecting the orientation and movement of edges in a scene is critical to visually guided
behaviors of many animals. What are the circuit algorithms that allow the brain to extract such …

Insects can perform impressive feats of navigation, suggesting a sophisticated sense of
direction and an ability to choose appropriate trajectories toward ethological goals. The …

Visual motion cues are used by many animals to guide navigation across a wide range of
environments. Long-standing theoretical models have made predictions about the …

Striatal medium‐sized spiny neurons (MSSNs) receive glutamatergic inputs modulated
presynaptically and postsynaptically by dopamine. Mice expressing the gene for enhanced …

Imbalance in the activity of striatal direct and indirect pathway neurons contributes to motor
disturbances in several neurodegenerative diseases. In Huntington's disease (HD), indirect …