User profiles for Yvonne Dombrowski

Yvonne Dombrowski

Queen's University Belfast
Verified email at qub.ac.uk
Cited by 8935

[HTML][HTML] QuPath: Open source software for digital pathology image analysis

…, MB Loughrey, JA Fernández, Y Dombrowski… - Scientific reports, 2017 - nature.com
QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly,
extensible, open-source solution for digital pathology and whole slide image analysis. …

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions

Y Dombrowski, M Peric, S Koglin… - Science translational …, 2011 - science.org
The proinflammatory cytokine interleukin-1β (IL-1β) plays a central role in the pathogenesis
and the course of inflammatory skin diseases, including psoriasis. Posttranscriptional …

[HTML][HTML] Oligodendrocytes in development, myelin generation and beyond

S Kuhn, L Gritti, D Crooks, Y Dombrowski - Cells, 2019 - mdpi.com
Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …

Regulatory T cells promote myelin regeneration in the central nervous system

Y Dombrowski, T O'hagan, M Dittmer, R Penalva… - Nature …, 2017 - nature.com
Regeneration of CNS myelin involves differentiation of oligodendrocytes from
oligodendrocyte progenitor cells. In multiple sclerosis, remyelination can fail despite abundant …

Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL …

…, J Glas, J Diegelmann, S Koglin, Y Dombrowski… - Gut, 2014 - gut.bmj.com
Background We analysed incidence, predictors, histological features and specific treatment
options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform skin lesions …

GDF-15 contributes to proliferation and immune escape of malignant gliomas

…, I Tritschler, M Mittelbronn, Y Dombrowski… - Clinical cancer …, 2010 - AACR
Purpose: Growth and differentiation factor (GDF)-15 is a member of the transforming growth
factor (TGF)-β family. GDF-15 is necessary for the maintenance of pregnancy but has also …

Antimicrobial peptides and proinflammatory cytokines in periprosthetic joint infection

H Gollwitzer, Y Dombrowski, PM Prodinger, M Peric… - JBJS, 2013 - journals.lww.com
Background: Differentiation between septic and aseptic loosening of joint replacements is
essential for successful revision surgery, but reliable markers for the diagnosis of low-grade …

Macrophage migration inhibitory factor contributes to the immune escape of ovarian cancer by down-regulating NKG2D

M Krockenberger, Y Dombrowski, C Weidler… - The Journal of …, 2008 - journals.aai.org
The proinflammatory cytokine macrophage migration inhibitory factor (MIF) stimulates tumor
cell proliferation, migration, and metastasis; promotes tumor angiogenesis; suppresses p53-…

[HTML][HTML] Vitamin D analogs differentially control antimicrobial peptide/“alarmin” expression in psoriasis

M Peric, S Koglin, Y Dombrowski, K Groß, E Bradac… - PloS one, 2009 - journals.plos.org
Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play
an important role as proinflammatory “alarmins” in this chronic skin disease. Vitamin D …

Aging impairs peritoneal but not bone marrow‐derived macrophage phagocytosis

E Linehan, Y Dombrowski, R Snoddy, PG Fallon… - Aging cell, 2014 - Wiley Online Library
Aging results in deterioration of the immune system, which is associated with increased
susceptibility to infection and impaired wound healing in the elderly. Phagocytosis is an …