The NADPH oxidase of professional phagocytes is a crucial component of the innate immune
response due to its fundamental role in the production of reactive oxygen species that act …

The multi-subunit NADPH oxidase complex plays a crucial role in host defense against
microbial infection through the production of reactive oxygen species. Activation of the NADPH …

The phagocyte NADPH oxidase is a multiprotein enzyme whose subunits are partitioned
between the cytosol and plasma membrane in resting cells. Upon exposure to appropriate …

Advances in head-mounted microscopes have enabled imaging of neuronal activity using
genetic tools in freely moving mice but these microscopes are restricted to recording in …

ClpB belongs to the Hsp100 family and assists de-aggregation of protein aggregates by
DnaK chaperone systems. It contains two Walker consensus sequences (or P-Loops) that …

ClpB from Thermus thermophilusbelongs to the Clp/Hsp100 protein family and reactivates
protein aggregates in cooperation with the DnaK chaperone system. The mechanism of …

The ubiquitin ligases c-Cbl and Cbl-b play a crucial role in receptor downregulation by
mediating multiple monoubiquitination of receptors and promoting their sorting for lysosomal …

The human peroxins PEX3 and PEX19 are essential for peroxisome biogenesis. They
mediate the import of membrane proteins as well as the de novo formation of peroxisomes. …

Hsp70 proteins like DnaK bind unfolded polypeptides in a nucleotide-dependent manner.
The switch from high-affinity ADP-state to low-affinity ATP-state with concomitant substrate …

Multiphoton imaging of genetically encoded calcium indicators is routinely used to report
activity from populations of spatially resolved neurons in vivo. However, since the relationship …