Regulation of mitochondrial proteostasis by the proton gradient
…, L Kroczek, M Ghosh, Y Ohba, Y Lasarzewski… - The EMBO …, 2022 - embopress.org
Mitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial
proteases are emerging as key regulators of these adaptive processes. Here, we use a …
proteases are emerging as key regulators of these adaptive processes. Here, we use a …
[HTML][HTML] A Drosophila Mitochondrial Complex I Deficiency Phenotype Array
S Foriel, GH Renkema, Y Lasarzewski… - Frontiers in …, 2019 - frontiersin.org
Mitochondrial diseases are a group of rare life-threatening diseases often caused by
defects in the oxidative phosphorylation system. No effective treatment is available for these …
defects in the oxidative phosphorylation system. No effective treatment is available for these …
A multiomic approach to identify new substrates of the human m-AAA protease
Y Lasarzewski - 2021 - kups.ub.uni-koeln.de
Mitochondria are essential organelles of eukaryotic cells and to ensure proper function
mitochondrial proteases consta Page 1 Abstract Mitochondria are essential organelles of …
mitochondrial proteases consta Page 1 Abstract Mitochondria are essential organelles of …
Mutations in the m-AAA proteases AFG3L2 and SPG7 are causing isolated dominant optic atrophy
M Charif, A Chevrollier, N Gueguen, C Bris… - Neurology …, 2020 - AAN Enterprises
Objective To improve the genetic diagnosis of dominant optic atrophy (DOA), the most
frequently inherited optic nerve disease, and infer genotype-phenotype correlations. Methods …
frequently inherited optic nerve disease, and infer genotype-phenotype correlations. Methods …
Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY
J Van Stelten, F Silva, D Belin, TJ Silhavy - Science, 2009 - science.org
Protein secretion occurs via translocation by the evolutionarily conserved Sec complex. LacZ
hybrid proteins have long been used to study translocation in Escherichia coli. Some LacZ …
hybrid proteins have long been used to study translocation in Escherichia coli. Some LacZ …
Bax Inhibitor-1 Is Likely a pH-Sensitive Calcium Leak Channel, Not a H+/Ca2+ Exchanger
G Bultynck, S Kiviluoto, A Methner - Science signaling, 2014 - science.org
The endoplasmic reticulum (ER) plays a key role in the synthesis, folding, and sorting of
proteins, and disturbances of this delicate system can cause cell death. The ER also serves as …
proteins, and disturbances of this delicate system can cause cell death. The ER also serves as …
Structural basis for a pH-sensitive calcium leak across membranes
Calcium homeostasis balances passive calcium leak and active calcium uptake. Human
Bax inhibitor–1 (hBI-1) is an antiapoptotic protein that mediates a calcium leak and is …
Bax inhibitor–1 (hBI-1) is an antiapoptotic protein that mediates a calcium leak and is …
Molecular characterization of protein translocation pores
M Ghosh - 2024 - ediss.uni-goettingen.de
In eukaryotic cells, many extracellular and soluble organellar proteins are synthesized on
cytosolic ribosomes and translocated to the ER, where they are being folded into their tertiary …
cytosolic ribosomes and translocated to the ER, where they are being folded into their tertiary …
[CITATION][C] Therapeutic Magnetic Nanoparticles: Targeting, Imaging and Treatment with Magnetic Fields
S Keller, SBPE Timmermans, MA Vermeulen - Radboud Honours Academy FNWI
[CITATION][C] Proteolytic rewiring of the mitochondria in hypoxia
C Srikanth