See Sarazin et al . (doi: 10.1093/brain/aww041 ) for a scientific commentary on this article.
The advent of the positron emission tomography tracer 18 F-AV1451 provides the unique …

Although behavioral variant frontotemporal dementia (bvFTD) is classically defined by
behavioral and socio-emotional changes, impairments often extend to other cognitive functions. …

Neuropathological and in vivo studies have revealed a tight relationship between tau
pathology and cognitive impairment across the Alzheimer’s disease spectrum. However, tau …

Objective To characterize in vivo signatures of pathological diagnosis in a large cohort of
patients with primary progressive aphasia (PPA) variants defined by current diagnostic …

β-Amyloid plaques and tau-containing neurofibrillary tangles are the two neuropathological
hallmarks of Alzheimer’s disease (AD) and are thought to play crucial roles in a …

Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies,
only to fail in human trials, suggesting a pressing need to study AD in human model systems…

Accurately predicting the underlying neuropathological diagnosis in patients with behavioural
variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will …

Co-pathologies play an important role in the expression of the Alzheimer’s disease clinical
phenotype and may influence treatment efficacy. Early-onset Alzheimer’s disease, defined as …

Determining the relative contribution of amyloid plaques and neurofibrillary tangles to brain
dysfunction in Alzheimer disease is critical for therapeutic approaches, but until recently …

Background The aetiology and pathogenesis of non-genetic forms of frontotemporal dementia
(FTD) is unknown and even with the genetic forms of FTD, pathogenesis remains elusive. …