The interplay between membrane proteins and the lipids of the membrane is important for
cellular function, however, tools enabling the interrogation of protein dynamics within native …

… State files contain information including m/z, maximum possible deuterium uptake,
observed deuterium uptake, standard deviation, retention time, and any residue modifications …

Other than more widely used methods, the use of styrene maleic acid allows the direct
extraction of membrane proteins from the lipid bilayer into SMALPs keeping it in its native lipid …

… Native mass spectrometry data on a Thermo Scientific Q Exactive UHMR hybrid
Quadrupole-orbitrap mass spectrometer was acquired at resolving power 8750 at m/z 400 in the m/z …

… All the spectra were examined and checked visually to ensure correct assignment of m/z
peaks and only peptides with a high signal to noise ratios were used for HDX-MS analysis. …

Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific
substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 …

Transport of proteins across membranes is a fundamental process, achieved in every cell
by the ‘Sec’ translocon. In prokaryotes, SecYEG associates with the motor ATPase SecA to …

… isolation window, CID fragmentation (NCE 28) with fixed first mass of 140.0 m/z, with a
17,500 resolution (at 200 m/z), 1 x 105 AGC target, 200 ms maximum injection time. The source …

LARP4A belongs to the ancient RNA-binding protein superfamily of La-related proteins (LARPs).
In humans, it acts mainly by stabilizing mRNAs, enhancing translation and controlling …

The HerA–NurA helicase–nuclease complex cooperates with Mre11 and Rad50 to coordinate
the repair of double-stranded DNA breaks. Little is known, however, about the assembly …