First triplets of mRNA coding region affect the yield of translation. We have applied the flowseq
method to analyze >30 000 variants of the codons 2–11 of the fluorescent protein reporter …

Translation efficiency contributes several orders of magnitude difference in the overall yield
of exogenous gene expression in bacteria. In diverse bacteria, the translation initiation site, …

… Z-score values obtained by the RNASurface program (Soldatov, Vinogradova & Mironov,
2013). Here, Z-score of a sequence is defined as Z = … the best (minimal) Z-score of all structured …

Trans-acting regulatory RNAs have the capacity to base pair with more mRNAs than generally
detected under defined conditions, raising the possibility that sRNA target specificities …

Motivation Identification of differentially expressed genes is necessary for unraveling disease
pathogenesis. This task is complicated by the fact that many diseases are heterogeneous …

RNA editing in the form of substituting adenine with inosine (A-to-I editing) is the most frequent
type of RNA editing in many metazoan species. In most species, A-to-I editing sites tend …

Deep learning is a class of machine learning techniques capable of creating internal
representation of data without explicit preprogramming. Hence, in addition to practical applications, …

The ribosome-dependent attenuator located upstream of bacterial tryptophan biosynthesis
genes harbors a small ORF trpL containing tryptophan codons. When tryptophan is available, …

Unsupervised patient stratification based on omics data is traditionally approached by clustering
methods which may be inefficient for datasets with multiple patterns overlapping in rows …

Neural networks are known to be good in generalising and discovery of novel non-trivial
patterns in complex data. Here we apply neural networks to several bioinformatic problems …