To maintain genome integrity in eukaryotes, DNA must be duplicated precisely once before
cell division occurs. A process called replication licensing ensures that chromosomes are …

Strict regulation of DNA replication is of fundamental significance for the maintenance of
genome stability. Licensing of origins of DNA replication is a critical event for timely genome …

Recent findings provide evidence for a functional interplay between DNA replication and
the seemingly distinct areas of cancer, development and pluripotency. Protein complexes …

To maintain genome stability in eukaryotic cells, DNA is licensed for replication only after the
cell has completed mitosis, ensuring that DNA synthesis (S phase) occurs once every cell …

Replication licensing is carefully regulated to restrict replication to once in a cell cycle. In
higher eukaryotes, regulation of the licensing factor Cdt1 by proteolysis and Geminin is …

S-phase onset is controlled, so that it occurs only once every cell cycle. DNA is licensed for
replication after mitosis in G 1 , and passage through S-phase removes the license to …

Very few of the enzymes required for eukaryotic precursor ribosomal RNA (pre-rRNA)
processing have been identified. Ribonuclease (RNase) MRP was characterized as a nuclease …

The accurate execution of DNA replication requires a strict control of the replication licensing
factors hCdt1 and hCdc6. The role of these key replication molecules in carcinogenesis …

We present easyFRAP, a versatile tool that assists quantitative and qualitative analysis of
fluorescence recovery after photobleaching (FRAP) data. The user can handle simultaneously …

… , Z Lygerou, and T Nishimoto, manuscript submitted for publication). The anti-hCdt1 rabbit
polyclonal antibody was previously described. Goat anti-mouse (Sigma) and anti-rabbit (Bio-…