Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists

…, AL Vyssotski, SG Brickley, R Yustos, ZE Pillidge… - Nature …, 2015 - nature.com
Do sedatives engage natural sleep pathways? It is usually assumed that anesthetic-induced
sedation and loss of righting reflex (LORR) arise by influencing the same circuitry to lesser …

[PDF][PDF] Activation of the Notch signaling pathway in vivo elicits changes in CSL nuclear dynamics

…, ML Jones, Z Pillidge, G Cerda-Moya, Z Yuan… - Developmental Cell, 2018 - cell.com
… For live imaging of Su(H)::GFP and Hairless::GFP nuclei the pinhole was set to 3-Airy
and Z-stacks spaced 0.5mm were taken to cover the volume of the nucleus using 512x512 …

[PDF][PDF] Notch mediates inter-tissue communication to promote tumorigenesis

H Boukhatmi, T Martins, Z Pillidge, T Kamenova, S Bray - Current Biology, 2020 - cell.com
Disease progression in many tumor types involves the interaction of genetically abnormal
cancer cells with normal stromal cells. Neoplastic transformation in a Drosophila genetic …

SWI/SNF chromatin remodeling controls Notch‐responsive enhancer accessibility

Z Pillidge, SJ Bray - EMBO reports, 2019 - embopress.org
Z by Tip60 supports Notch‐dependent gene expression 10. However, none of these studies
Z deposition and acetylation directs the canonical Notch signaling response. Nucleic Acids …

[HTML][HTML] Role of co-repressor genomic landscapes in shaping the Notch response

…, L Skalska, M Gomez-Lamarca, Z Pillidge… - PLoS …, 2017 - journals.plos.org
Repressors are frequently deployed to limit the transcriptional response to signalling pathways.
For example, several co-repressors interact directly with the DNA-binding protein CSL …

Transcription and chromatin dynamics in the Notch signalling response

Z Pillidge - 2019 - repository.cam.ac.uk
Z presence at the +1 nucleosome, and that histone H2A.Z levels were low at strong
circadian promoters, suggesting that genes … Z/H2B dimers and the INO80 complex does the …

Oligosaccharides in goats' milk-based infant formula and their prebiotic and anti-infection properties

…, Z Liu, H Almshawit, B Zisu, C Pillidge… - British Journal of …, 2019 - cambridge.org
… One of the minor milk oligosaccharides, N-acetyl-glucosaminyl-lactose (m/z 544·18) was
found to be absent in raw goats’ milk (Table 1, Fig. 3), and S2-GIF had slightly higher …

HSD42 Modelling Time and Costs Associated With Daratumumab Treatment Delivery in the Home Care Setting Versus the Hospital in Spain to Understand Potential …

A Asra, Z Pillidge, A Clark, M Ronchi… - Value in …, 2022 - valueinhealthjournal.com
Objectives Subcutaneous (SC) formulations of daratumumab replace the previous need for
intravenous infusion, potentially enabling treatment to be provided at alternative sites of care. …

[HTML][HTML] New insights into cheddar cheese microbiota-metabolome relationships revealed by integrative analysis of multi-omics data

R Afshari, CJ Pillidge, E Read, S Rochfort, DA Dias… - Scientific Reports, 2020 - nature.com
Cheese microbiota and metabolites and their inter-relationships that underpin specific
cheese quality attributes remain poorly understood. Here we report that multi-omics and …

Defective post-replication recovery and UV sensitivity in a simian virus 40-transformed Indian muntjac cell line

L Pillidge, CS Downes, RT Johnson - International Journal of …, 1986 - Taylor & Francis
The responses to uv of two cell lines derived from the Indian muntjac are described. The uv
sensitivity of the diploid cell falls within the range of most normal mammalian cells while the …