User profiles for Zabrina L. Brumme
 | Zabrina BrummeAssociate Professor, Faculty of Health Sciences, Simon Fraser University Verified email at sfu.ca Cited by 12753 |
[HTML][HTML] Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients
Background Nucleoside analogues can induce toxic effects on mitochondria by inhibiting the
human DNA polymerase γ. The toxic effects can range from increased serum lactate levels …
human DNA polymerase γ. The toxic effects can range from increased serum lactate levels …
Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy
Objective. The objective of this study was to systematically characterize the incidence and
determinants of antiretroviral resistance in the HOMER (Highly Active Antiretroviral Therapy […
determinants of antiretroviral resistance in the HOMER (Highly Active Antiretroviral Therapy […
[HTML][HTML] Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection
Deep sequencing technologies have the potential to transform the study of highly variable
viral pathogens by providing a rapid and cost-effective approach to sensitively characterize …
viral pathogens by providing a rapid and cost-effective approach to sensitively characterize …
Influence of HLA-C expression level on HIV control
A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant
genome-wide effect on HIV control in European Americans and is also associated with the level of …
genome-wide effect on HIV control in European Americans and is also associated with the level of …
HLA-B57/B* 5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong …
Human immunodeficiency virus type 1 (HIV-1) elite controllers (EC) maintain viremia below
the limit of commercial assay detection (<50 RNA copies/ml) in the absence of antiviral …
the limit of commercial assay detection (<50 RNA copies/ml) in the absence of antiviral …
Molecular and clinical epidemiology of CXCR4-using HIV-1 in a large population of antiretroviral-naive individuals
ZL Brumme, J Goodrich, HB Mayer… - The Journal of …, 2005 - academic.oup.com
ObjectiveWe wished to characterize the epidemiological and clinical correlates of CXCR4-using
human immunodeficiency virus type 1 (HIV-1) (“X4 variants”) in a cross-sectional …
human immunodeficiency virus type 1 (HIV-1) (“X4 variants”) in a cross-sectional …
[HTML][HTML] Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells
H Streeck, ZL Brumme, M Anastario, KW Cohen… - PLoS …, 2008 - journals.plos.org
Background Virus-specific CD8 + T lymphocytes play a key role in the initial reduction of
peak viremia during acute viral infections, but display signs of increasing dysfunction and …
peak viremia during acute viral infections, but display signs of increasing dysfunction and …
[HTML][HTML] Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient-and …
…, JI Brooks, CAB Boucher, ZL Brumme… - PLoS …, 2015 - journals.plos.org
Background Regional and subtype-specific mutational patterns of HIV-1 transmitted drug
resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines …
resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines …
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection
…, S Darko, MA Brockman, T Miura, ZL Brumme… - Nature …, 2012 - nature.com
The human leukocyte antigens HLA-B*27 and HLA-B*57 are associated with protection
against progression of disease that results from infection with human immunodeficiency virus …
against progression of disease that results from infection with human immunodeficiency virus …
[HTML][HTML] Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial
…, CJ Petropoulos, J Martinez-Picado, ZL Brumme… - Nature medicine, 2022 - nature.com
Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …