Growth factors, such as insulin, can induce both acute and long-term glucose uptake into
cells. Apart from the rapid, insulin-induced fusion of glucose transporter (GLUT)4 storage …

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species
including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (…

Ovarian cancer ranks as the most deadly gynecologic cancer, and there is an urgent need
to develop more effective therapies. Previous studies have shown that G9A, a histone …

Osteocalcin (OCN), the most abundant noncollagenous protein in the bone matrix, is reported
to be a bone-derived endocrine hormone with wide-ranging effects on many aspects of …

Background Suicide risk assessments are often challenging for clinicians, and therefore,
biological markers are warranted as guiding tools in these assessments. Suicidal patients …

There is a great need to develop novel approaches to target oncogenic transcription factors
with small molecules. Ewing sarcoma is emblematic of this need, as it depends on the …

Purpose: The goal of this study was to identify second-generation mithramycin analogues
that better target the EWS-FLI1 transcription factor for Ewing sarcoma. We previously …

The key negative regulatory gene of the RAS pathway, NF1, is mutated or deleted in numerous
cancer types and is associated with increased cancer risk and drug resistance. Even …

Uterine fibroids (leiomyomas) affect Black women disproportionately compared with women
of other races and ethnicities in terms of prevalence, incidence, and severity of symptoms. …

Here, we provide an in-depth analysis of the usefulness of single-sample metabolite/RNA
extraction for multi-‘omics readout. Using pulverized frozen livers of mice injected with …