We present an extensive assessment of mutation burden through sequencing analysis of >81,000
tumors from pediatric and adult patients, including tumors with hypermutation caused …

Multiple DNA polymerases participate in replicating the leading and lagging strands of the
eukaryotic nuclear genome. Although 50 years have passed since the first DNA polymerase …

DNA replication−associated mutations are repaired by two components: polymerase
proofreading and mismatch repair. The mutation consequences of disruption to both repair …

Exome- and genome-wide MSI analysis reveals novel signatures that are uniquely attributed
to mismatch repair and DNA polymerase. This provides new mechanistic insight into MS …

Replication of the mitochondrial genome by DNA polymerase γ requires dNTP precursors
that are subject to oxidation by reactive oxygen species generated by the mitochondrial …

The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA
polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase ε (Pol ε) is the …

Bulk replicative DNA synthesis in eukaryotes is highly accurate and efficient, primarily because
of two DNA polymerases (Pols): Pols δ and ε. The high fidelity of these enzymes is due to …

… Lead Contact Further information and requests for resources and reagents should be
addressed to the Lead Contact, Zachary F. Pursell (zpursell@ tulane.edu), Department of …

Tumors with somatic mutations in the proofreading exonuclease domain of DNA polymerase
epsilon (POLE-exo*) exhibit a novel mutator phenotype, with markedly elevated TCT→TAT …

The mutation rate of the mammalian mitochondrial genome is higher than that of the nuclear
genome. Because mitochondrial and nuclear deoxyribonucleoside triphosphate (dNTP) …