User profiles for Zachary K Barth
 | Zachary K BarthPostdoctoral Associate, Virginia Tech Verified email at berkeley.edu Cited by 283 |
Widespread CRISPR-derived RNA regulatory elements in CRISPR-Cas systems
CRISPR-cas loci typically contain CRISPR arrays with unique spacers separating direct
repeats. Spacers along with portions of adjacent repeats are transcribed and processed into …
repeats. Spacers along with portions of adjacent repeats are transcribed and processed into …
[HTML][HTML] A highly specific phage defense system is a conserved feature of the Vibrio cholerae mobilome
Vibrio cholerae-specific bacteriophages are common features of the microbial community
during cholera infection in humans. Phages impose strong selective pressure that favors the …
during cholera infection in humans. Phages impose strong selective pressure that favors the …
Bacteriophage ICP1: A Persistent Predator of Vibrio cholerae
Bacteriophages or phages—viruses of bacteria—are abundant and considered to be highly
diverse. Interestingly, a particular group of lytic Vibrio cholerae–specific phages (…
diverse. Interestingly, a particular group of lytic Vibrio cholerae–specific phages (…
A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites
ZK Barth, MHT Nguyen, KD Seed - Elife, 2021 - elifesciences.org
Mobile genetic elements, elements that can move horizontally between genomes, have
profound effects on their host's fitness. The phage-inducible chromosomal island-like element (…
profound effects on their host's fitness. The phage-inducible chromosomal island-like element (…
A phage parasite deploys a nicking nuclease effector to inhibit viral host replication
KN LeGault, ZK Barth, P DePaola IV… - Nucleic acids …, 2022 - academic.oup.com
PLEs (phage-inducible chromosomal island-like elements) are phage parasites integrated
into the chromosome of epidemic Vibrio cholerae. In response to infection by its viral host …
into the chromosome of epidemic Vibrio cholerae. In response to infection by its viral host …
Genome replication dynamics of a bacteriophage and its satellite reveal strategies for parasitism and viral restriction
Phage-inducible chromosomal island-like elements (PLEs) are bacteriophage satellites
found in Vibrio cholerae. PLEs parasitize the lytic phage ICP1, excising from the bacterial …
found in Vibrio cholerae. PLEs parasitize the lytic phage ICP1, excising from the bacterial …
Nuclease genes occupy boundaries of genetic exchange between bacteriophages
ZK Barth, DT Dunham, KD Seed - NAR Genomics and …, 2023 - academic.oup.com
Homing endonuclease genes (HEGs) are ubiquitous selfish elements that generate targeted
double-stranded DNA breaks, facilitating the recombination of the HEG DNA sequence into …
double-stranded DNA breaks, facilitating the recombination of the HEG DNA sequence into …
A family of viral satellites manipulates invading virus gene expression and can affect cholera toxin mobilization
Many viruses possess temporally unfolding gene expression patterns aimed at subverting
host defenses, commandeering host metabolism, and ultimately producing a large number of …
host defenses, commandeering host metabolism, and ultimately producing a large number of …
[HTML][HTML] Widespread CRISPR repeat-like RNA regulatory elements in CRISPR-Cas systems
CRISPR-cas loci typically contain CRISPR arrays with unique spacers separating direct
repeats. Spacers along with portions of adjacent repeats are transcribed and processed into …
repeats. Spacers along with portions of adjacent repeats are transcribed and processed into …
Caenorhabditis elegans glutamylating enzymes function redundantly in male mating
Microtubule glutamylation is an important modulator of microtubule function and has been
implicated in the regulation of centriole stability, neuronal outgrowth and cilia motility. …
implicated in the regulation of centriole stability, neuronal outgrowth and cilia motility. …