The prediction of cellular function from a genotype is a fundamental goal in biology. For
metabolism, constraint-based modelling methods systematize biochemical, genetic and genomic …

Genome-scale metabolic models are mathematically-structured knowledge bases that can
be used to predict metabolic pathway usage and growth phenotypes. Furthermore, they can …

To the Editor—Reconstructing metabolic reaction networks enables the development of
testable hypotheses of an organism’s metabolism under different conditions 1. State-of-the-art …

In her News Feature “Biotech’s green gold” 1, Emily Waltz details the ‘hype’being propagated
around emerging microalgal biofuel technologies, which often exceeds the physical and …

Figure 1 iML1515 genome-scale reconstruction.(a) The iML1515 model contains 1,515 open
reading frames that encode enzymes that catalyze 2,719 reactions involving 1,192 unique …

Escher is a web application for visualizing data on biological pathways. Three key features
make Escher a uniquely effective tool for pathway visualization. First, users can rapidly …

Cortical neural prostheses require chronically implanted small-area microelectrode arrays
that simultaneously record and stimulate neural activity. It is necessary to develop new …

Chinese hamster ovary (CHO) cells dominate biotherapeutic protein production and are widely
used in mammalian cell line engineering research. To elucidate metabolic bottlenecks in …

… Author links open overlay panel Zachary A King 1 , Colton J Lloyd 1 , Adam M Feist 1 2 ,
Bernhard O Palsson 1 2 3 … Bordbar, JM Monk, ZA King, BØPalsson … ZA King, AM Feist …

The BiGG Models knowledge base ( http://bigg.ucsd.edu ) is a centralized repository for high-quality
genome-scale metabolic models. For the past 12 years, the website has allowed …