[HTML][HTML] Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
Glaucoma, a leading cause of irreversible blindness, is a highly heritable human disease.
Previous genome-wide association studies have identified over 100 loci for the most common …
Previous genome-wide association studies have identified over 100 loci for the most common …
Population genetics of the coral Acropora millepora: Toward genomic prediction of bleaching
INTRODUCTION Coral reefs worldwide are suffering losses at an alarming rate as a result of
anthropogenic climate change. Increased seawater temperatures, even only slightly above …
anthropogenic climate change. Increased seawater temperatures, even only slightly above …
Measuring intolerance to mutation in human genetics
In numerous applications, from working with animal models to mapping the genetic basis of
human disease susceptibility, knowing whether a single disrupting mutation in a gene is …
human disease susceptibility, knowing whether a single disrupting mutation in a gene is …
Spatially varying selection between habitats drives physiological shifts and local adaptation in a broadcast spawning coral on a remote atoll in Western Australia
At the Rowley Shoals in Western Australia, the prominent reef flat becomes exposed on low
tide and the stagnant water in the shallow atoll lagoons heats up, creating a natural …
tide and the stagnant water in the shallow atoll lagoons heats up, creating a natural …
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs
Causal loss-of-function (LOF) variants for Mendelian and severe complex diseases are enriched
in'mutation intolerant'genes. We show how such observations can be interpreted in light …
in'mutation intolerant'genes. We show how such observations can be interpreted in light …
[HTML][HTML] Investigating the viral ecology of global bee communities with high-throughput metagenomics
Bee viral ecology is a fascinating emerging area of research: viruses exert a range of effects
on their hosts, exacerbate impacts of other environmental stressors, and, importantly, are …
on their hosts, exacerbate impacts of other environmental stressors, and, importantly, are …
[HTML][HTML] Ancestral polymorphisms explain the role of chromosomal inversions in speciation
ZL Fuller, CJ Leonard, RE Young, SW Schaeffer… - PLoS …, 2018 - journals.plos.org
Understanding the role of chromosomal inversions in speciation is a fundamental problem
in evolutionary genetics. Here, we perform a comprehensive reconstruction of the …
in evolutionary genetics. Here, we perform a comprehensive reconstruction of the …
How chromosomal rearrangements shape adaptation and speciation: Case studies in Drosophila pseudoobscura and its sibling species Drosophila persimilis
The gene arrangements of Drosophila have played a prominent role in the history of
evolutionary biology from the original quantification of genetic diversity to current studies of the …
evolutionary biology from the original quantification of genetic diversity to current studies of the …
A food-predictive cue attributed with incentive salience engages subcortical afferents and efferents of the paraventricular nucleus of the thalamus
The paraventricular nucleus of the thalamus (PVT) has been implicated in behavioral responses
to reward-associated cues. However, the precise role of the PVT in these behaviors has …
to reward-associated cues. However, the precise role of the PVT in these behaviors has …
Environmental specialization and cryptic genetic divergence in two massive coral species from the Florida Keys Reef Tract
Broadcast‐spawning coral species have wide geographical ranges spanning strong
environmental gradients, but it is unclear how much spatially varying selection these gradients …
environmental gradients, but it is unclear how much spatially varying selection these gradients …