[HTML][HTML] Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine

…, X Liu, AC Cole, L Pessaint, D Valentin, Z Flinchbaugh… - Nature, 2022 - nature.com
The CVnCoV (CureVac) mRNA vaccine for severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) was recently evaluated in a phase 2b/3 efficacy trial in humans 1 . CV2CoV …

[HTML][HTML] Protective efficacy of Ad26. COV2. S against SARS-CoV-2 B. 1.351 in macaques

…, K Bauer, L Pessaint, D Valentin, Z Flinchbaugh… - Nature, 2021 - nature.com
The emergence of SARS-CoV-2 variants that partially evade neutralizing antibodies poses
a threat to the efficacy of current COVID-19 vaccines 1 , 2 . The Ad26.COV2.S vaccine …

A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P. 1 (Gamma) …

…, A Cook, B Narvaez, Z Flinchbaugh… - ACS infectious …, 2022 - ACS Publications
FDA-approved and emergency use-authorized vaccines using new mRNA and viral-vector
technology are highly effective in preventing moderate to severe disease; however, …

Optimization of non-coding regions improves protective efficacy of an mRNA SARS-CoV-2 vaccine in nonhuman primates

…, X Liu, AC Cole, L Pessaint, D Valentin, Z Flinchbaugh… - BioRxiv, 2021 - biorxiv.org
The CVnCoV (CureVac) mRNA vaccine for SARS-CoV-2 has recently been evaluated in a
phase 2b/3 efficacy trial in humans. CV2CoV is a second-generation mRNA vaccine with …

Protein Vaccine Induces a Durable, More Broadly Neutralizing Antibody Response in Macaques than Natural Infection with SARS-CoV-2 P. 1

…, N Daham, A Cook, B Narvaez, Z Flinchbaugh… - bioRxiv, 2021 - biorxiv.org
FDA-approved and Emergency Use Authorized (EUA) vaccines using new mRNA and viral-vector
technology are highly effective in preventing moderate to severe disease, however, …

[HTML][HTML] Development of multivalent mRNA vaccine candidates for seasonal or pandemic influenza

S Chivukula, T Plitnik, T Tibbitts, S Karve, A Dias… - npj Vaccines, 2021 - nature.com
Recent approval of mRNA vaccines for emergency use against COVID-19 is likely to promote
rapid development of mRNA-based vaccines targeting a wide range of infectious diseases. …

[HTML][HTML] Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

MF Tioni, R Jordan, AS Pena, A Garg, D Wu, SI Phan… - npj Vaccines, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the COVID-19 global pandemic. SARS-CoV-2 is an enveloped RNA virus that relies on its …

The business of publishing professional magazines and journals has its own hierarchy of the unappreciated and underappreciated. The professional staff who actually …

…, RE Finch, GO Fischer, D Fisher, B Flinchbaugh… - 1992 - computer.org
But the medal for Least Appreciated goes to the referees who give their time to review the
submitted articles, and who pretty much assure the quality and relevance of a magazine such …

Colorectal cancer screening education, prioritization, and self-perceived preparedness among primary care residents: Data from a national survey

…, WO Petersen, JC Kolars, RT Flinchbaugh… - Journal of Cancer …, 2007 - Springer
Background. Colorectal cancer (CRC) screening remains underutilized in the United States.
We conducted a national survey of CRC screening education, prioritization, and self-…

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

MT Mabrouk, K Chiem, E Rujas, WC Huang… - Science …, 2021 - science.org
The COVID-19 pandemic has spurred interest in potent and thermostable SARS-CoV-2
vaccines. Here, we assess low-dose immunization with lyophilized nanoparticles decorated with …