A key challenge in understanding and ultimately treating autism is to identify common
molecular mechanisms underlying this genetically heterogeneous disorder. Transcriptomic …

Huntington’s disease (HD) is classically characterized as a movement disorder, however
cognitive impairments precede the motor symptoms by ∼15 y. Based on proteomic and …

10.7554/eLife.28270.001 KCC2 is a neuron-specific K + -Cl – cotransporter essential for
establishing the Cl - gradient required for hyperpolarizing inhibition in the central nervous …

Amyotrophic lateral sclerosis is a fatal disease resulting from motor neuron degeneration in
the cortex and spinal cord. Cortical hyperexcitability is a hallmark feature of amyotrophic …

Olfactory processing is thought to be actively modulated by the top-down input from cortical
regions, but the behavioural function of these signals remains unclear. Here we find that …

Synaptic inhibition depends on a transmembrane gradient of chloride, which is set by the
neuron-specific K + -Cl − co-transporter KCC2. Reduced KCC2 levels in the neuronal …

Neto2 is a transmembrane protein that interacts with the neuron-specific K + -Cl − cotransporter
(KCC2) in the central nervous system (CNS). Efficient KCC2 transport is essential for …

Huntington’s disease (HD) is a genetic neurodegenerative disorder of the central nervous
system characterized by choreatic movements, behavioral and psychiatric disturbances and …

In neuroendocrine cells, hormone release often requires a collective burst of action
potentials synchronized by gap junctions. This is the case for the electrically coupled bag cell …

… Trotter1,*,#, Zahra Dargaei1,*, Markus Wöhr1,&, Kif Liakath-Ali1, Karthik Raju1, …
Roppongi, RT, Dhume, SH, Padmanabhan, N., Silwal, P., Zahra, N., Karimi, B., Bomkamp, C …