10.7554/eLife.04066.001 Both pathogen- and tissue damage-associated molecular
patterns induce inflammation through toll-like receptors (TLRs), while sialic acid-binding …

Influenza viruses cause seasonal flu each year and pandemics or epidemic sporadically,
posing a major threat to public health. Recently, a new influenza D virus (IDV) was isolated …

The need for atom‐precise biomolecule modification, and particularly the irreversible formation
of covalent bonds to specific amino acids in proteins, has become an essential issue in …

In order to understand the biological importance of naturally occurring sialic acid variations
on disialyl structures in nature, we developed an efficient two-step multienzyme approach for …

Ruminococcus gnavus is a human gut symbiont wherein the ability to degrade mucins is
mediated by an intramolecular trans-sialidase (RgNanH). RgNanH comprises a GH33 catalytic …

Serine-rich repeat glycoproteins are adhesins expressed by commensal and pathogenic
Gram-positive bacteria. A subset of these adhesins, expressed by oral streptococci, binds …

Background N-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic
acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains …

Sialic acids (Sias) are important glycans displayed on the cells and tissues of many different
animals and are frequent targets for binding and modification by pathogens, including …

9-O-Acetylation is a common natural modification on sialic acids (Sias) that terminate many
vertebrate glycan chains. This ester group has striking effects on many biological phenomena…

A series of STn-MUC1 and ST-MUC1 glycopeptides containing naturally occurring and non-natural
sialic acids have been chemoenzymatically synthesized from Tn-MUC1 glycopeptide …