The trafficking of G protein coupled‐receptors (GPCRs) is one of the most exciting areas in
cell biology because of recent advances demonstrating that GPCR signaling is spatially …

Vesicle fusion at the plasma membrane is critical for releasing hormones and neurotransmitters
and for delivering the cognate G protein–coupled receptors (GPCRs) to the cell surface. …

Peer review is an important part of the scientific process, but traditional peer review at
journals is coming under increased scrutiny for its inefficiency and lack of transparency. As …

Several GPCRs, including receptors previously thought to signal primarily from the cell
surface, have been recently shown to signal from many intracellular compartments. This raises …

The prevailing model for the variety in drug responses is that different drugs stabilize distinct
active states of their G protein-coupled receptor (GPCR) targets, allowing coupling to …

Background and Purpose The δ‐opioid receptor is an emerging target for the management
of chronic pain and depression. Biased signalling, the preferential activation of one …

Functional selectivity at the µ opioid receptor (µR), a prototypical G-protein–coupled receptor
that is a physiologically relevant target for endogenous opioid neurotransmitters and …

G protein-coupled receptor (GPCR) kinases (GRKs) play a key role in terminating signals
initiated by agonist-bound GPCRs. However, chronic stimulation of GPCRs, such as that which …

Preprints enable new forms of peer review that have the potential to be more thorough,
inclusive, and collegial. In December 2022, 80 researchers and representatives of funders, …

Membrane trafficking and receptor signaling are two fundamental cellular processes that
interact constantly. Although how trafficking regulates signaling is well studied, how signaling …