Dopaminergic neurons in the ventral tegmental area (VTA) fire spontaneously in a pacemaker-like
manner. We analyzed the ionic currents that drive pacemaking in dopaminergic VTA …

Transmission from striatal cholinergic interneurons (CINs) controls dopamine release through
nicotinic acetylcholine receptors (nAChRs) on dopaminergic axons. Anatomical studies …

Information flow in neurons proceeds by integrating inputs in dendrites, generating action
potentials near the soma, and releasing neurotransmitters from nerve terminals in the axon. …

10.7554/eLife.40984.001 Dopamine (D2) receptors provide autoinhibitory feedback onto
dopamine neurons through well-known interactions with voltage-gated calcium channels and …

Substantia nigra dopamine neurons fire tonically resulting in action potential backpropagation
and dendritic Ca 2+ influx. Using Ca 2+ imaging in acute mouse brain slices, we find a …

Purkinje neurons generate high-frequency action potentials and express voltage-gated,
tetrodotoxin-sensitive sodium channels with distinctive kinetics. Their sodium currents activate …

Among the known genetic risk factors for Parkinson disease, mutations in GBA1, the gene
responsible for the lysosomal disorder Gaucher disease, are the most common. This genetic …

In cerebellar Purkinje neurons, the reliability of propagation of high-frequency simple spikes
and spikelets of complex spikes is likely to regulate inhibition of Purkinje target neurons. To …

Neuronal excitability is likely to be regulated by the site of action potential initiation, the location
on a neuron that crosses threshold first. Although initiation is axonal in many neurons, in …

The Scn8a gene encodes the voltage-gated Na channel α subunit Na V 1.6, which is widely
expressed throughout the nervous system. Global null mutations that eliminate Scn8a in all …