Ubiquitin ligases in oncogenic transformation and cancer therapy
The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis…
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis…
Metabolic rewiring in melanoma
…, DA Scott, AL Osterman, JW Smith, ZA Ronai - Oncogene, 2017 - nature.com
Oncogene-driven metabolic rewiring is an adaptation to low nutrient and oxygen conditions
in the tumor microenvironment that enables cancer cells of diverse origin to hyperproliferate. …
in the tumor microenvironment that enables cancer cells of diverse origin to hyperproliferate. …
ATF2–at the crossroad of nuclear and cytosolic functions
… Eric Lau, Ze'ev A. Ronai; ATF2 – at the crossroad of nuclear and cytosolic functions. J
Cell Sci 15 June 2012; 125 (12): 2815–2824. doi: https://doi.org/10.1242/jcs.095000 …
Cell Sci 15 June 2012; 125 (12): 2815–2824. doi: https://doi.org/10.1242/jcs.095000 …
G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
ZA Ronai, S Gradia, LA Peterson, SS Hecht - Carcinogenesis, 1993 - academic.oup.com
Lung tumors were induced in A/J mice by the tobacco-specific nitrosamine
4Kmethylnitrosaniino)-1-(3-pyridyI)-1-butanone (NNK) and the related compounds …
4Kmethylnitrosaniino)-1-(3-pyridyI)-1-butanone (NNK) and the related compounds …
Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
The tricarboxylic acid (TCA) cycle is the central hub of oxidative metabolism, running in the
classic forward direction to provide carbon for biosynthesis and reducing agents for …
classic forward direction to provide carbon for biosynthesis and reducing agents for …
[HTML][HTML] Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice
…, T Long, SN Peterson, LM Bradley, ZA Ronai - Nature …, 2019 - nature.com
Accumulating evidence points to an important role for the gut microbiome in anti-tumor
immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, …
immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, …
PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity
Protein arginine methyltransferase 5 (PRMT5) controls diverse cellular processes and is
implicated in cancer development and progression. Here, we report an inverse correlation …
implicated in cancer development and progression. Here, we report an inverse correlation …
The state of melanoma: challenges and opportunities
…, S Silverstein, T Turnham, ZA Ronai - Pigment cell & …, 2016 - Wiley Online Library
The Melanoma Research Foundation ( MRF ) has charted a comprehensive assessment of
the current state of melanoma research and care. Intensive discussions among members of …
the current state of melanoma research and care. Intensive discussions among members of …
[HTML][HTML] Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection
Autophagy is the mechanism by which cytoplasmic components and organelles are degraded
by the lysosomal machinery in response to diverse stimuli including nutrient deprivation, …
by the lysosomal machinery in response to diverse stimuli including nutrient deprivation, …
Targeting the Warburg effect via LDHA inhibition engages ATF 4 signaling for cancer cell survival
Nutrient restriction reprograms cellular signaling and metabolic network to shape cancer
phenotype. Lactate dehydrogenase A ( LDHA ) has a key role in aerobic glycolysis (the …
phenotype. Lactate dehydrogenase A ( LDHA ) has a key role in aerobic glycolysis (the …