Recent studies indicate that long noncoding RNAs (lncRNAs) can act as competing
endogenous RNAs (ceRNAs) to indirectly regulate mRNAs through shared microRNAs, which …

Background Recent single-cell RNA sequencing (scRNA-seq) analyses have offered much
insight into cell-specific gene expression profiles in normal kidneys. However, in diseased …

Various ‘omics’ technologies, including microarrays and gas chromatography mass spectrometry,
can be used to identify hundreds of interesting genes, proteins and metabolites, such …

The pathogenesis of diabetic kidney disease (DKD) involves multifactorial processes that
converge to initiate and advance the disease. Although DKD is not typically classified as an …

To identify the factors mediating the progression of diabetic nephropathy (DN), we performed
RNA sequencing of kidney biopsy samples from patients with early DN, advanced DN, and …

Apolipoprotein L1 (APOL1) risk alleles in donor kidneys associate with graft loss, but whether
recipient risk allele expression affects transplant outcomes is unclear. To test whether …

Background In kidney transplant recipients, surveillance biopsies can reveal, despite stable
graft function, histologic features of acute rejection and borderline changes that are …

Background Long Interspersed Nuclear Element-1 (LINE-1, L1) is increasingly regarded as
a genetic risk for lung cancer. Transcriptionally active LINE-1 forms a L1-gene chimeric …

Renal inflammation and fibrosis are the common pathways leading to progressive chronic
kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as …

Interstitial fibrosis, tubular atrophy, and inflammation are major contributors to kidney allograft
failure. Here we sought an objective, quantitative pathological assessment of these lesions …