Background Abundant evidence shows that triple-negative breast cancer (TNBC) is
heterogeneous, and many efforts have been devoted to identifying TNBC subtypes on the basis of …

Immune checkpoint inhibitor (ICI) therapy can induce complete responses in mismatch
repair-deficient and microsatellite instability-high (d-MMR/MSI-H) colorectal cancers (CRCs). …

Triple-negative breast cancer (TNBC) is a high-risk malignancy due to its high capacity for
invasion and lack of targeted therapy. Immunotherapy continues to demonstrate efficacy in a …

Background Prior studies showed that tumor glycolysis and tumor immune evasion are
interdependent. However, a systematic investigation of the association between tumor glycolysis …

Although immunotherapy continues to demonstrate efficacy in a variety of refractory cancers,
currently, no any immunotherapeutic strategy is clinically used for gastric cancer (GC) …

Although immunotherapy has emerged as an effective therapeutic strategy for various cancers
including head and neck squamous cell carcinomas (HNSCCs), only a subset of patients …

Because traditional treatment strategies for advanced gastrointestinal (GI) cancers often have
a limited therapeutic effect, immunotherapy could be a viable approach for the therapy of …

Background. Although immunotherapy has recently achieved clinical successes in a variety
of cancers, thus far there is no immunotherapeutic strategy for breast cancer (BC). Thus, it is …

Retinoblastoma (RB) is the most common primary intraocular malignancy of childhood. It is
known that the tumor microenvironment (TME) regulates tumorigenesis and metastasis. …

A complete characterization of genetic variation is a fundamental goal of human genome
research. Long-read sequencing has improved the sensitivity of structural variant discovery. …