User profiles for Zekun Mu
 | Zekun MuRockefeller University Verified email at rockefeller.edu Cited by 822 |
[HTML][HTML] HIV mRNA vaccines—progress and future paths
The SARS-CoV-2 pandemic introduced the world to a new type of vaccine based on mRNA
encapsulated in lipid nanoparticles (LNPs). Instead of delivering antigenic proteins directly, …
encapsulated in lipid nanoparticles (LNPs). Instead of delivering antigenic proteins directly, …
[PDF][PDF] A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice
SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high
transmissibility of the virus and the high rate of morbidity and mortality associated with COVID-19…
transmissibility of the virus and the high rate of morbidity and mortality associated with COVID-19…
FTO inhibition enhances the antitumor effect of temozolomide by targeting MYC-miR-155/23a cluster-MXI1 feedback circuit in glioma
These findings elucidate a novel feedback loop that regulates proliferation in glioma and
can be targeted via inhibition of FTO to enhance the efficacy of temozolomide. …
can be targeted via inhibition of FTO to enhance the efficacy of temozolomide. …
[HTML][HTML] Cold sensitivity of the SARS-CoV-2 spike ectodomain
The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development,
presents its receptor binding domain in two conformations, the receptor-accessible ‘up’ or …
presents its receptor binding domain in two conformations, the receptor-accessible ‘up’ or …
[HTML][HTML] Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified
mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of …
mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of …
miR-142-5p enhances cisplatin-induced apoptosis in ovarian cancer cells by targeting multiple anti-apoptotic genes
Chemotherapy is the preferred treatment for advanced ovarian cancer, but the 5-year survival
rate remains low partly because of the development of drug resistance. Although it has …
rate remains low partly because of the development of drug resistance. Although it has …
[PDF][PDF] mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice
The success of nucleoside-modified mRNAs in lipid nanoparticles (mRNA-LNP) as COVID-19
vaccines heralded a new era of vaccine development. For HIV-1, multivalent envelope (…
vaccines heralded a new era of vaccine development. For HIV-1, multivalent envelope (…
Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination
A prophylactic vaccine would be a powerful tool in the fight against HIV. Passive immunization
of animals with broadly neutralizing antibodies (bnAbs) affords protection against viral …
of animals with broadly neutralizing antibodies (bnAbs) affords protection against viral …
CO2 emission reduction potential in China's electricity sector: scenario analysis based on LMDI decomposition
B Gu, X Tan, Y Zeng, Z Mu - Energy Procedia, 2015 - Elsevier
The CO 2 emission reduction from China's electricity sector will matter not only for China but
impact the result of the global action on climate change. This paper firstly analyzed the main …
impact the result of the global action on climate change. This paper firstly analyzed the main …
Structure-based stabilization of SOSIP Env enhances recombinant ectodomain durability and yield
The envelope glycoprotein (Env) is the main focus of human immunodeficiency virus type 1 (HIV-1)
vaccine development due to its critical role in viral entry. Despite advances in protein …
vaccine development due to its critical role in viral entry. Despite advances in protein …