Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the
genetic alterations in this tumor type, we searched for copy number alterations using high-…

Glioblastomas exhibit vast inter- and intra-tumoral heterogeneity, complicating the development
of effective therapeutic strategies. Current in vitro models are limited in preserving the …

Cancers comprise a heterogeneous group of human diseases. Unifying characteristics
include unchecked abilities of tumor cells to proliferate and spread anatomically, and the …

Recurrent glioblastoma (rGBM) remains a major unmet medical need, with a median overall
survival of less than 1 year. Here we report the first six patients with rGBM treated in a phase …

We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR)
extracellular domain missense mutations. Retrospective assessment of 260 de novo …

The remarkable heterogeneity of glioblastoma, across patients and over time, is one of the
main challenges in precision diagnostics and treatment planning. Non-invasive in vivo …

Glioblastoma is the most common aggressive adult brain tumor. Numerous studies have
reported results from either private institutional data or publicly available datasets. However, …

We generated two humanized interleukin-13 receptor α2 (IL-13Rα2) chimeric antigen
receptors (CARs), Hu07BBz and Hu08BBz, that recognized human IL-13Rα2, but not IL-13Rα1. …

We analyze transposable elements (TEs) in glioblastoma (GBM) patients using a
proteogenomic pipeline that combines single-cell transcriptomics, bulk RNA sequencing (RNA-seq) …

Malignant solid tumors are characterized by aberrant vascularity that fuels the formation of
an immune-hostile microenvironment and induces resistance to immunotherapy. Vascular …