Single-cell RNA sequencing (scRNA-seq) data are commonly affected by technical artifacts
known as "doublets," which limit cell throughput and lead to spurious biological conclusions. …

The translation of nucleic acid libraries into corresponding synthetic compounds would
enable selection and amplification principles to be applied to man-made molecules. We used …

Sample multiplexing facilitates scRNA-seq by reducing costs and identifying artifacts such as
cell doublets. However, universal and scalable sample barcoding strategies have not been …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic alterations
that enable uncontrolled growth and expansion to neighboring and distal tissues. The …

Despite their limited chemical functionality, proteins and nucleic acids dominate the solutions
to many complex chemical problems because they can be evolved through iterated cycles …

Multicellular organs comprise differentiated cell types with discrete yet interdependent functions.
The cells' spatial arrangements and interconnectivities, both critical elements of higher-…

Proteins are the primary effectors of cellular function, including cellular metabolism, structural
dynamics, and information processing. However, quantitative characterization of proteins …

Microglia are resident macrophages in the brain that emerge in early development and respond
to the local environment by altering their molecular and phenotypic states. Fundamental …

Reconstituting tissues from their cellular building blocks facilitates the modeling of morphogenesis,
homeostasis and disease in vitro. Here we describe DNA-programmed assembly of …

Current single-cell RNA-sequencing approaches have limitations that stem from the microfluidic
devices or fluid handling steps required for sample processing. We develop a method …