User profiles for Zeyad D. Nassar

Zeyad D Nassar

School of Medicine, University of Adelaide
Verified email at adelaide.edu.au
Cited by 1828

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

ZD Nassar, CY Mah, J Dehairs, IJG Burvenich, S Irani… - Elife, 2020 - elifesciences.org
Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa)
and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy …

[HTML][HTML] Correlation of antiangiogenic, antioxidant and cytotoxic activities of some Sudanese medicinal plants with phenolic and flavonoid contents

…, HM Baharetha, NS Muslim, ZD Nassar… - … and alternative medicine, 2014 - Springer
Background Consumption of medicinal plants to overcome diseases is traditionally belongs
to the characteristics of most cultures on this earth. Sudan has been a host and cradle to …

Lipidomic profiling of clinical prostate cancer reveals targetable alterations in membrane lipid composition

…, T Gevaert, R Derua, E Waelkens, ZD Nassar… - Cancer research, 2021 - AACR
This study identifies malignancy and treatment-associated changes in lipid composition of
clinical prostate cancer tissues, suggesting that mediators of these lipidomic changes could …

ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer

MM Centenera, JS Scott, J Machiels, ZD Nassar… - Cancer research, 2021 - AACR
… B–D, Phospholipidomic changes in total lipid abundance, abundance per lipid class, and
saturation in LNCaP cells following treatment with synthetic androgen mibolerone. Data, mean …

Extracellular fatty acids are the major contributor to lipid synthesis in prostate cancer

S Balaban, ZD Nassar, AY Zhang… - Molecular Cancer …, 2019 - AACR
Extracellular-derived FAs are primary building blocks for complex lipids and heterogeneity
in FA metabolism exists in prostate cancer that can influence tumor cell behavior. …

Peri‐prostatic adipose tissue: the metabolic microenvironment of prostate cancer

ZD Nassar, AT Aref, D Miladinovic, CY Mah… - BJU …, 2018 - Wiley Online Library
Emerging data have linked certain features of clinical prostate cancer ( PC a) to obesity and,
more specifically, increased adiposity. Whereas the large number of clinical studies and …

[HTML][HTML] PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis

ZD Nassar, H Moon, T Duong, LQ Neo, MM Hill… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Caveolae are specialized plasma membrane subdomains implicated in cellular functions
such as migration, signalling and trafficking. Caveolin-1 and polymerase I and transcript …

Cat's whiskers tea (Orthosiphon stamineus) extract inhibits growth of colon tumor in nude mice and angiogenesis in endothelial cells via suppressing VEGFR …

MBK Ahamed, AFA Aisha, ZD Nassar… - Nutrition and …, 2012 - Taylor & Francis
Cat's whiskers (Orthosiphon stamineus) is commonly used as Java tea to treat kidney
stones including a variety of angiogenesis-dependent diseases such as tumorous edema, …

[HTML][HTML] Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1

H Moon, JE Ruelcke, E Choi, LJ Sharpe, ZD Nassar… - Oncotarget, 2015 - ncbi.nlm.nih.gov
… The HC-D group showed higher bioluminescence intensity in the para-aortic lymph node
(p = 0.0007, Figure ​1g), mesenteric lymph node (p = 0.0021, Figure ​1h) and the lung (p = …

Activation of μ-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice

…, T Vithanage, ZD Nassar, PJ Cabot, D Sturgess… - Brain, behavior, and …, 2017 - Elsevier
In this study, we quantified the ability of opioids present in biological samples to activate the
μ-opioid receptor and TLR4 using cell-based assays. Each assay was standardised, in the …