Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation
is challenging. To better understand common genetic variation associated with brain …

Spalt-like transcription factor 1 (SALL1) is a critical regulator of organogenesis and microglia
identity. Here we demonstrate that disruption of a conserved microglia-specific super-…

Prior exposure to microenvironmental signals could fundamentally change the response of
macrophages to subsequent stimuli. It is believed that T helper-2 (Th2)-cell-type cytokine …

Mechanisms by which members of the AP-1 family of transcription factors play non-redundant
biological roles despite recognizing the same DNA sequence remain poorly understood. …

Mechanisms by which noncoding genetic variation influences gene expression remain only
partially understood but are considered to be major determinants of phenotypic diversity and …

Background Metagenome-assembled genomes have greatly expanded the reference
genomes for skin microbiome. However, the current reference genomes are largely based on …

Macrophage activation is controlled by a balance between activating and inhibitory receptors
1 , 2 , 3 , 4 , 5 , 6 – 7 , which protect normal tissues from excessive damage during infection …

The complex interplay between microbiota and immunity is important to human health. To
explore how altered adaptive immunity influences the microbiome, we characterize skin, nares…

Motivation Genetic variation in regulatory elements can alter transcription factor (TF) binding
by mutating a TF binding motif, which in turn may affect the activity of the regulatory elements…

Cardiovascular diseases, especially atherosclerosis and its complications, are a leading cause
of death. Inhibition of the noncanonical IκB kinases TANK-binding kinase 1 and IKKε with …