Since its establishment in 2009, single-cell RNA sequencing (RNA-seq) has been a major
driver behind progress in biomedical research. In developmental biology and stem cell studies…

Fungal infections by drug-resistant Candida albicans pose a global public health threat.
However, the pathogen’s diploid genome greatly hinders genome-wide investigations of …

Kras-activating mutations display the highest incidence in pancreatic ductal adenocarcinoma.
Pancreatic inflammation accelerates mutant Kras-driven tumorigenesis in mice, …

RNA molecules are highly compartmentalized in eukaryotic cells, with their localizations
intimately linked to their functions. Despite the importance of RNA targeting, our current …

The subcellular organization of biomolecules such as proteins and nucleic acids is intimately
linked to their biological functions. APEX2, an engineered ascorbate peroxidase that …

Friction stir processing (FSP) was successfully applied to modify the microstructure and texture
of an Mg-8Gd-5Y-1.1Nd-0.45Zr (wt.%) alloy. Two kinds of original alloys, ie, solid solution …

Importance Localization of small lung nodules are challenging because of the difficulty of
nodule recognition during video-assisted thoracoscopic surgery. Using 3-dimensional (3-D) …

New SARS-CoV-2 mutants have been continuously indentified with enhanced transmission
ever since its outbreak in early 2020. As an RNA virus, SARS-CoV-2 has a high mutation …

Background Small pulmonary nodules are a common problem, especially with the wide
implementation of lung cancer–screening program. This poses a great challenge to thoracic …

Type I restriction-modification (RM) systems consist of a DNA endonuclease (HsdR, HsdM
and HsdS subunits) and methyltransferase (HsdM and HsdS subunits). The hsdS sequences …