[HTML][HTML] Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients

…, ZMA Groothuismink, BJ Beudeker, Z Osmani… - Hepatology, 2023 - journals.lww.com
Single-cell RNA sequencing of liver fine-needle aspirates ca... : Hepatology Single-cell RNA
sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in …

[HTML][HTML] Recent insights into the role of B cells in chronic hepatitis B and C infections

Z Osmani, A Boonstra - Pathogens, 2023 - mdpi.com
Chronic viral hepatitis infections, caused by the hepatitis B or C virus, are a major global health
problem causing an estimated one million deaths each year. Immunological studies have …

A reverse translational study on the effect of rituximab, rituximab plus belimumab, or bortezomib on the humoral autoimmune response in SLE

LS van Dam, Z Osmani, SWA Kamerling, T Kraaij… - …, 2020 - academic.oup.com
Objectives SLE is a severe autoimmune disease characterized by autoreactive B cells and
IC formation, which causes systemic inflammation. B cell–targeted therapy could be a …

Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific …

…, ZMA Groothuismink, BJ Beudeker, Z Osmani… - BioRxiv, 2021 - biorxiv.org
Blood samples are frequently collected in human studies of the immune system but poorly
represent tissue-resident immunity. Understanding the immunopathogenesis of tissue-…

Hydroxychloroquine treatment in European patients with lupus erythematosus: dosing, retinopathy screening and adherence

Z Osmani, TJ Schrama, W Zacouris-Verweij… - Lupus Science & …, 2021 - lupus.bmj.com
Background Use of hydroxychloroquine (HCQ) is common in patients with lupus erythematosus.
Long-term use (ie, ≥5 years) and high-dose HCQ (ie, >5 mg/kg/day) are both risk …

Standardised immunophenotypic analysis of myeloperoxidase in acute leukaemia

AE Bras, Z Osmani, V de Haas… - British journal of …, 2021 - Wiley Online Library
Given its myeloid‐restricted expression, myeloperoxidase (MPO) is typically used for lineage
assignment (myeloid vs. lymphoid) during acute leukaemia (AL) diagnostics. In the present …

[HTML][HTML] Association of HBsAg levels with differential gene expression in NK, CD8 T, and memory B cells in treated patients with chronic HBV

BJB Beudeker, Z Osmani, GW van Oord… - JHEP Reports, 2024 - Elsevier
Background & Aims HBsAg secretion may impact immune responses to chronic HBV infection.
Thus, therapeutic approaches to suppress HBsAg production are being investigated. Our …

POS0185 belimumab disrupts memory B-cell trafficking in patients with systemic lupus erythematosus

EJ Arends, M Zlei, CM Tipton, J Cotic, Z Osmani… - 2022 - ard.bmj.com
Background Belimumab (BEL), a recombinant human monoclonal antibody directed against
B-cell activating factor (BAFF), is the first approved biological agent for patients with active …

MO257 BELIMUMAB ADD-ON THERAPY MOBILIZES MEMORY B CELLS INTO CIRCULATION OF SLE PATIENTS

EJ Arends, M Zlei, CM Tipton, Z Osmani… - Nephrology Dialysis …, 2021 - academic.oup.com
Abstracts Page 1 CONCLUSION: In patients with IgAN, associations were seen between
treatment effects of RASB on proteinuria and on the clinically relevant endpoints of renal events …

MO246: Belimumab Disrupts Memory B Cell Trafficking in Patients with Systemic Lupus Erythematosus

EJ Arends, M Zlei, CM Tipton, Z Osmani… - Nephrology Dialysis …, 2022 - academic.oup.com
BACKGROUND AND AIMS Belimumab (BEL), a recombinant human monoclonal antibody
directed against B-cell activating factor (BAFF), is the first approved biological agent for …