User profiles for Zhana Duren
Zhana DurenAssistant Professor, Center for Human Genetics, Clemson University Verified email at clemson.edu Cited by 1799 |
Integrative analysis of single-cell genomics data by coupled nonnegative matrix factorizations
When different types of functional genomics data are generated on single cells from different
samples of cells from the same heterogeneous population, the clustering of cells in the …
samples of cells from the same heterogeneous population, the clustering of cells in the …
Modeling gene regulation from paired expression and chromatin accessibility data
The rapid increase of genome-wide datasets on gene expression, chromatin states, and
transcription factor (TF) binding locations offers an exciting opportunity to interpret the …
transcription factor (TF) binding locations offers an exciting opportunity to interpret the …
[HTML][HTML] Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
High-altitude adaptation of Tibetans represents a remarkable case of natural selection during
recent human evolution. Previous genome-wide scans found many non-coding variants …
recent human evolution. Previous genome-wide scans found many non-coding variants …
Time course regulatory analysis based on paired expression and chromatin accessibility data
A time course experiment is a widely used design in the study of cellular processes such as
differentiation or response to stimuli. In this paper, we propose time course regulatory …
differentiation or response to stimuli. In this paper, we propose time course regulatory …
Subspace matching pursuit for sparse unmixing of hyperspectral data
Sparse unmixing assumes that each mixed pixel in the hyperspectral image can be expressed
as a linear combination of only a few spectra (endmembers) in a spectral library, known a …
as a linear combination of only a few spectra (endmembers) in a spectral library, known a …
[HTML][HTML] Unsupervised clustering and epigenetic classification of single cells
Characterizing epigenetic heterogeneity at the cellular level is a critical problem in the modern
genomics era. Assays such as single cell ATAC-seq (scATAC-seq) offer an opportunity to …
genomics era. Assays such as single cell ATAC-seq (scATAC-seq) offer an opportunity to …
Dynamic chromatin regulatory landscape of human CAR T cell exhaustion
Dysfunction in T cells limits the efficacy of cancer immunotherapy. We profiled the epigenome,
transcriptome, and enhancer connectome of exhaustion-prone GD2-targeting HA-28z …
transcriptome, and enhancer connectome of exhaustion-prone GD2-targeting HA-28z …
[PDF][PDF] TFAP2C-and p63-dependent networks sequentially rearrange chromatin landscapes to drive human epidermal lineage commitment
Tissue development results from lineage-specific transcription factors (TFs) programming a
dynamic chromatin landscape through progressive cell fate transitions. Here, we define …
dynamic chromatin landscape through progressive cell fate transitions. Here, we define …
Integrated functional genomic analyses of Klinefelter and Turner syndromes reveal global network effects of altered X chromosome dosage
…, T Ward, M Ho, R Pattni, Z Duren… - Proceedings of the …, 2020 - National Acad Sciences
In both Turner syndrome (TS) and Klinefelter syndrome (KS) copy number aberrations of the
X chromosome lead to various developmental symptoms. We report a comparative analysis …
X chromosome lead to various developmental symptoms. We report a comparative analysis …
[HTML][HTML] DC3 is a method for deconvolution and coupled clustering from bulk and single-cell genomics data
Characterizing and interpreting heterogeneous mixtures at the cellular level is a critical
problem in genomics. Single-cell assays offer an opportunity to resolve cellular level …
problem in genomics. Single-cell assays offer an opportunity to resolve cellular level …