User profiles for Zhen Lin
Zhen Lin, MD, PhDTulane University School of Medicine Verified email at tulane.edu Cited by 3819 |
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
…, M Goudreault, B Muskat, C Alfarano, D Dewar, Z Lin… - Nature, 2002 - nature.com
The recent abundance of genome sequence data has brought an urgent need for systematic
proteomics to decipher the encoded protein networks that dictate cellular function 1 . To …
proteomics to decipher the encoded protein networks that dictate cellular function 1 . To …
The genetic landscape of a cell
…, RL Brost, Y Chen, M Cokol, R Deshpande, Z Li, ZY Lin… - science, 2010 - science.org
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene
pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles …
pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles …
The CRAPome: a contaminant repository for affinity purification–mass spectrometry data
…, D Fermin, WH Dunham, M Goudreault, ZY Lin… - Nature …, 2013 - nature.com
Affinity purification coupled with mass spectrometry (AP-MS) is a widely used approach for
the identification of protein-protein interactions. However, for any given protein of interest, …
the identification of protein-protein interactions. However, for any given protein of interest, …
A global genetic interaction network maps a wiring diagram of cellular function
…, M Billmann, J Van Leeuwen, N Van Dyk, ZY Lin… - Science, 2016 - science.org
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
Expert knowledge based valuation method of ecosystem services in China
G XIE, L Zhen, C LU, Y Xiao, C Chen - Journal of Natural Resources, 2008 - jnr.ac.cn
Valuation of global ecosystem services by R Costanza(1997)has attracted attention of the
Chinese ecological researchers over the years. And many Chinese scientists have been using …
Chinese ecological researchers over the years. And many Chinese scientists have been using …
A global protein kinase and phosphatase interaction network in yeast
…, JR Sharom, L Boucher, V Neduva, B Larsen, ZY Lin… - Science, 2010 - science.org
The interactions of protein kinases and phosphatases with their regulatory subunits and
substrates underpin cellular regulation. We identified a kinase and phosphatase interaction (KPI…
substrates underpin cellular regulation. We identified a kinase and phosphatase interaction (KPI…
SAINT: probabilistic scoring of affinity purification–mass spectrometry data
H Choi, B Larsen, ZY Lin, A Breitkreutz… - Nature …, 2011 - nature.com
We present 'significance analysis of interactome' (SAINT), a computational tool that assigns
confidence scores to protein-protein interaction data generated using affinity purification–…
confidence scores to protein-protein interaction data generated using affinity purification–…
Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways
D Zhou, C Huang, Z Lin, S Zhan, L Kong, C Fang, J Li - Cellular signalling, 2014 - Elsevier
Monocytes/macrophages are heterogeneous and versatile cells that could undergo their
phenotypically/functionally dynamic switch in response to the microenvironment signals. Two …
phenotypically/functionally dynamic switch in response to the microenvironment signals. Two …
Impact of land use change on ecosystem services: A review
Abstract Changes in land use and ecosystem services influence each other and such changes
have consequences for human wellbeing. In this paper, we review the research literature …
have consequences for human wellbeing. In this paper, we review the research literature …
The shieldin complex mediates 53BP1-dependent DNA repair
…, MM Munro, A McEwan, T Goullet de Rugy, ZY Lin… - Nature, 2018 - nature.com
53BP1 is a chromatin-binding protein that regulates the repair of DNA double-strand breaks
by suppressing the nucleolytic resection of DNA termini 1 , 2 . This function of 53BP1 …
by suppressing the nucleolytic resection of DNA termini 1 , 2 . This function of 53BP1 …