The recent abundance of genome sequence data has brought an urgent need for systematic
proteomics to decipher the encoded protein networks that dictate cellular function 1 . To …

A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene
pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles …

Affinity purification coupled with mass spectrometry (AP-MS) is a widely used approach for
the identification of protein-protein interactions. However, for any given protein of interest, …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Valuation of global ecosystem services by R Costanza(1997)has attracted attention of the
Chinese ecological researchers over the years. And many Chinese scientists have been using …

The interactions of protein kinases and phosphatases with their regulatory subunits and
substrates underpin cellular regulation. We identified a kinase and phosphatase interaction (KPI…

We present 'significance analysis of interactome' (SAINT), a computational tool that assigns
confidence scores to protein-protein interaction data generated using affinity purification–…

Monocytes/macrophages are heterogeneous and versatile cells that could undergo their
phenotypically/functionally dynamic switch in response to the microenvironment signals. Two …

Abstract Changes in land use and ecosystem services influence each other and such changes
have consequences for human wellbeing. In this paper, we review the research literature …

53BP1 is a chromatin-binding protein that regulates the repair of DNA double-strand breaks
by suppressing the nucleolytic resection of DNA termini 1 , 2 . This function of 53BP1 …