The human body is composed of diverse cell types with distinct functions. Although it is
known that lineage specification depends on cell-specific gene expression, which in turn is …

The Warburg effect, which originally described increased production of lactate in cancer, is
associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of …

We report the identification of 67 previously undescribed histone modifications, increasing
the current number of known histone marks by about 70%. We further investigated one of the …

DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular
processes including genome regulation, development and disease. Here we present the …

The laboratory mouse shares the majority of its protein-coding genes with humans, making
it the premier model organism in biomedical research, yet the two mammals differ in …

Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …

The laboratory mouse is the most widely used mammalian model organism in biomedical
research. The 2.6 × 10 9 bases of the mouse genome possess a high degree of conservation …

A large number of cis-regulatory sequences have been annotated in the human genome 1 ,
2 , but defining their target genes remains a challenge 3 . One strategy is to identify the long-…

Objective To assess the prevalence of diabetes and its risk factors. Design Population based,
cross sectional study. Setting 31 provinces in mainland China with nationally …

Excessive cerebral accumulation of the 42-residue amyloid β-protein (Aβ) is an early and
invariant step in the pathogenesis of Alzheimer's disease. Many studies have examined the …