User profiles for Zheng-Rong Lu
 | Zheng-Rong LuCase Western Reserve University Verified email at case.edu Cited by 10242 |
HPMA copolymer–anticancer drug conjugates: design, activity, and mechanism of action
The design, synthesis and properties of N-(2-hydroxypropyl)methacrylamide (HPMA)
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics based on …
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics based on …
A peptide targeted contrast agent specific to fibrin-fibronectin complexes for cancer molecular imaging with MRI
A peptide targeted contrast agent, CLT1-(Gd-DTPA), was synthesized for molecular imaging
of fibronectin−fibrin complexes in tumor tissue with magnetic resonance imaging (MRI). The …
of fibronectin−fibrin complexes in tumor tissue with magnetic resonance imaging (MRI). The …
Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates
Purpose. Overexpression of hyaluronan (HA) receptors on cancer cells results in enhanced
endocytotic uptake of the drug conjugate. An N-(2-hydroxypropyl)methacrylamide (HPMA)-…
endocytotic uptake of the drug conjugate. An N-(2-hydroxypropyl)methacrylamide (HPMA)-…
[HTML][HTML] MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent
Metastasis is the primary cause of death in breast cancer patients. Early detection of high-risk
breast cancer, including micrometastasis, is critical in tailoring appropriate and effective …
breast cancer, including micrometastasis, is critical in tailoring appropriate and effective …
Systemic delivery of tumor-targeting siRNA nanoparticles against an oncogenic LncRNA facilitates effective triple-negative breast cancer therapy
Long noncoding RNAs (lncRNAs), by virtue of their versatility and multilevel gene regulation,
have emerged as attractive pharmacological targets for treating heterogeneous and …
have emerged as attractive pharmacological targets for treating heterogeneous and …
Targeted contrast agents for magnetic resonance molecular imaging of cancer
Conspectus Magnetic resonance imaging (MRI) is a clinical imaging modality that provides
high-resolution images of soft tissues, including cancerous lesions. Stable gadolinium(III) …
high-resolution images of soft tissues, including cancerous lesions. Stable gadolinium(III) …
Gadolinium‐based contrast agents for magnetic resonance cancer imaging
Magnetic resonance imaging (MRI) is a clinical imaging modality effective for anatomical
and functional imaging of diseased soft tissues, including solid tumors. MRI contrast agents (CA…
and functional imaging of diseased soft tissues, including solid tumors. MRI contrast agents (CA…
In vitro release of 5-fluorouracil with cyclic core dendritic polymer
RX Zhuo, B Du, ZR Lu - Journal of controlled release, 1999 - Elsevier
This paper describes the first synthesis of a series of dendritic polymers with a core of 1,4,7,10-tetraazacyclododecane.
This core was allowed to react with methyl acrylate through a …
This core was allowed to react with methyl acrylate through a …
Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier
TL Kaneshiro, ZR Lu - Biomaterials, 2009 - Elsevier
Codelivery of different therapeutics has a potential to efficaciously treat human diseases via
their synergetic effects. We have recently developed a new class dendrimers, poly(l-lysine) …
their synergetic effects. We have recently developed a new class dendrimers, poly(l-lysine) …
Molecular imaging of the tumor microenvironment
The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix, …
and resistance to therapy. It is different from normal tissue in the extracellular matrix, …