Relaxin is an antifibrotic peptide hormone previously assumed to directly reverse the activation
of hepatic stellate cells for liver fibrosis resolution. Using nanoparticle-mediated delivery, …

We report a multilevel modified vertebral column resection (MVCR) through a single posterior
approach and clinical outcomes for treatment of severe congenital rigid kyphoscoliosis in …

Background Hepatocellular carcinoma (HCC) developed in fibrotic liver does not respond
well to immunotherapy, mainly due to the stromal microenvironment and the fibrosis-related …

Surgical treatment of complex severe spinal deformity, involving a scoliosis Cobb angle of
more than 90 and kyphosis or vertebral and rib deformity, is challenging. Preoperative two-…

Survival of KRAS mutant pancreatic cancer is critically dependent on reprogrammed metabolism
including elevated macropinocytosis, autophagy, and lysosomal degradation of proteins…

Study Design. A retrospective analysis of patients undergoing spinal deformity correction
surgery by the assistance of intraoperative computed tomography (iCT) with or without …

Activation of the hepatic stellate cells (HSCs) is a key pathogenic event in liver fibrosis.
Protein S-glutathionylation (PSSG) of cysteine residues is a distinct form of oxidative response …

Pancreatic ductal adenocarcinoma (PDAC) is a dominantly (~95%) KRAS-mutant cancer
that has extremely poor prognosis, in part this is due to its strong intrinsic resistance towards …

Background: Pancreatic cancer comprises not only cancer cells but also a collection of cross-talking
noncancerous cells within tumor. Therefore, selective delivery of cytotoxic agents …

Cancers remain a threat to human health due to the lack of effective therapeutic strategies.
Great effort has been devoted to the discovery of drug targets to treat cancers, but novel …