User profiles for Zhenning Tan
Zhenning TanGoogle Research, Indiana University, Georgia Institute of Technology Verified email at google.com Cited by 945 |
Core protein: A pleiotropic keystone in the HBV lifecycle
Hepatitis B Virus (HBV) is a small virus whose genome has only four open reading frames.
We argue that the simplicity of the virion correlates with a complexity of functions for viral …
We argue that the simplicity of the virion correlates with a complexity of functions for viral …
Characterization of hepatitis B virus capsids by resistive-pulse sensing
We report characterization of hepatitis B virus (HBV) capsids by resistive-pulse sensing
through single track-etched conical nanopores formed in poly(ethylene terephthalate) …
through single track-etched conical nanopores formed in poly(ethylene terephthalate) …
[PDF][PDF] Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure
Hepatitis B virus (HBV) is a major cause of liver disease. Assembly of the HBV capsid is a
critical step in virus production and an attractive target for new antiviral therapies. We …
critical step in virus production and an attractive target for new antiviral therapies. We …
Nanofluidic devices with two pores in series for resistive-pulse sensing of single virus capsids
…, K Zhou, BW Hildenbrand, I Mitra, Z Tan… - Analytical …, 2011 - ACS Publications
We report fabrication and characterization of nanochannel devices with two nanopores in
series for resistive-pulse sensing of hepatitis B virus (HBV) capsids. The nanochannel and two …
series for resistive-pulse sensing of hepatitis B virus (HBV) capsids. The nanochannel and two …
The interface between hepatitis B virus capsid proteins affects self-assembly, pregenomic RNA packaging, and reverse transcription
Z Tan, K Pionek, N Unchwaniwala, ML Maguire… - Journal of …, 2015 - Am Soc Microbiol
Hepatitis B virus (HBV) capsid proteins (Cps) assemble around the pregenomic RNA (pgRNA)
and viral reverse transcriptase (P). pgRNA is then reverse transcribed to double-stranded …
and viral reverse transcriptase (P). pgRNA is then reverse transcribed to double-stranded …
Genetically altering the thermodynamics and kinetics of hepatitis B virus capsid assembly has profound effects on virus replication in cell culture
Z Tan, ML Maguire, DD Loeb, A Zlotnick - Journal of virology, 2013 - Am Soc Microbiol
Capsid (core) assembly is essential for hepatitis B virus (HBV) replication. We hypothesize
that assembly kinetics and stability are tuned for optimal viral replication, not maximal …
that assembly kinetics and stability are tuned for optimal viral replication, not maximal …
Structurally similar woodchuck and human hepadnavirus core proteins have distinctly different temperature dependences of assembly
Woodchuck hepatitis virus (WHV), a close relative of human hepatitis B virus (HBV), has
been a key model for disease progression and clinical studies. Sequences of the assembly …
been a key model for disease progression and clinical studies. Sequences of the assembly …
OpenFEAT: Improving speaker identification by open-set few-shot embedding adaptation with Transformer
Household speaker identification with few enrollment utterances is an important yet challenging
problem, especially when household members share similar voice characteristics and …
problem, especially when household members share similar voice characteristics and …
[PDF][PDF] One protein, at least three structures, and many functions
Hepatitis B virus core gene products can adopt different conformations to perform their
functional roles. In this issue of Structure, DiMattia and colleagues show the crystal structure of …
functional roles. In this issue of Structure, DiMattia and colleagues show the crystal structure of …
Improving speaker identification for shared devices by adapting embeddings to speaker subsets
Speaker identification typically involves three stages. First, a front-end speaker embedding
model is trained to embed utterance and speaker profiles. Second, a scoring function is …
model is trained to embed utterance and speaker profiles. Second, a scoring function is …