User profiles for Zhenze Jiang
Zhenze JiangRoche Verified email at roche.com Cited by 555 |
[HTML][HTML] Skin commensal Malassezia globosa secreted protease attenuates Staphylococcus aureus biofilm formation
H Li, BN Goh, WK Teh, Z Jiang, JPZ Goh, A Goh… - Journal of Investigative …, 2018 - Elsevier
Skin provides the first defense against pathogenic micro-organisms and is also colonized by
a diverse microbiota. Phylogenetic analysis of whole skin microbiome at different skin sites …
a diverse microbiota. Phylogenetic analysis of whole skin microbiome at different skin sites …
Selective neutral pH inhibitor of cathepsin B designed based on cleavage preferences at cytosolic and lysosomal pH conditions
Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein
degradation, but in numerous human diseases, cathepsin B translocates to the cytosol …
degradation, but in numerous human diseases, cathepsin B translocates to the cytosol …
Targeting proteasomes in infectious organisms to combat disease
B Bibo‐Verdugo, Z Jiang, CR Caffrey… - The FEBS …, 2017 - Wiley Online Library
Proteasomes are multisubunit, energy‐dependent, proteolytic complexes that play an
essential role in intracellular protein turnover. They are present in eukaryotes, archaea, and in …
essential role in intracellular protein turnover. They are present in eukaryotes, archaea, and in …
Dysregulation of neuropeptide and tau peptide signatures in human Alzheimer's disease brain
S Podvin, Z Jiang, B Boyarko, LA Rossitto… - ACS Chemical …, 2022 - ACS Publications
Synaptic dysfunction and loss occur in Alzheimer’s disease (AD) brains, which results in
cognitive deficits and brain neurodegeneration. Neuropeptides comprise the major group of …
cognitive deficits and brain neurodegeneration. Neuropeptides comprise the major group of …
[HTML][HTML] The Pseudomonas aeruginosa protease LasB directly activates IL-1β
Background Pulmonary damage by Pseudomonas aeruginosa during cystic fibrosis lung
infection and ventilator-associated pneumonia is mediated both by pathogen virulence factors …
infection and ventilator-associated pneumonia is mediated both by pathogen virulence factors …
[HTML][HTML] Dysregulation of exosome cargo by mutant tau expressed in human-induced pluripotent stem cell (iPSC) neurons revealed by proteomics analyses
Accumulation and propagation of hyperphosphorylated Tau (p-Tau) is a common
neuropathological hallmark associated with neurodegeneration of Alzheimer's disease (AD), …
neuropathological hallmark associated with neurodegeneration of Alzheimer's disease (AD), …
Differential neuropeptidomes of dense core secretory vesicles (DCSV) produced at intravesicular and extracellular pH conditions by proteolytic processing
Neuropeptides mediate cell–cell signaling in the nervous and endocrine systems. The
neuropeptidome is the spectrum of peptides generated from precursors by proteolysis within …
neuropeptidome is the spectrum of peptides generated from precursors by proteolysis within …
[HTML][HTML] Quantitative multiplex substrate profiling of peptidases by mass spectrometry
Proteolysis is an integral component of life and has been implicated in many disease processes.
To improve our understanding of peptidase function, it is imperative to develop tools to …
To improve our understanding of peptidase function, it is imperative to develop tools to …
[HTML][HTML] SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties
Background Serine proteases are important virulence factors for many pathogens. Recently,
we discovered a group of trypsin-like serine proteases with domain organization unique to …
we discovered a group of trypsin-like serine proteases with domain organization unique to …
The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni
Proteases are fundamental to successful parasitism, including that of the schistosome flatworm
parasite, which causes the disease schistosomiasis in 200 million people worldwide. The …
parasite, which causes the disease schistosomiasis in 200 million people worldwide. The …