User profiles for Zhenze Jiang

Zhenze Jiang

Roche
Verified email at roche.com
Cited by 555

[HTML][HTML] Skin commensal Malassezia globosa secreted protease attenuates Staphylococcus aureus biofilm formation

H Li, BN Goh, WK Teh, Z Jiang, JPZ Goh, A Goh… - Journal of Investigative …, 2018 - Elsevier
Skin provides the first defense against pathogenic micro-organisms and is also colonized by
a diverse microbiota. Phylogenetic analysis of whole skin microbiome at different skin sites …

Selective neutral pH inhibitor of cathepsin B designed based on cleavage preferences at cytosolic and lysosomal pH conditions

MC Yoon, A Solania, Z Jiang, MP Christy… - ACS chemical …, 2021 - ACS Publications
Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein
degradation, but in numerous human diseases, cathepsin B translocates to the cytosol …

Targeting proteasomes in infectious organisms to combat disease

B Bibo‐Verdugo, Z Jiang, CR Caffrey… - The FEBS …, 2017 - Wiley Online Library
Proteasomes are multisubunit, energy‐dependent, proteolytic complexes that play an
essential role in intracellular protein turnover. They are present in eukaryotes, archaea, and in …

Dysregulation of neuropeptide and tau peptide signatures in human Alzheimer's disease brain

S Podvin, Z Jiang, B Boyarko, LA Rossitto… - ACS Chemical …, 2022 - ACS Publications
Synaptic dysfunction and loss occur in Alzheimer’s disease (AD) brains, which results in
cognitive deficits and brain neurodegeneration. Neuropeptides comprise the major group of …

[HTML][HTML] The Pseudomonas aeruginosa protease LasB directly activates IL-1β

…, EA Skowronski, JM Kimmey, J Olson, Z Jiang… - …, 2020 - thelancet.com
Background Pulmonary damage by Pseudomonas aeruginosa during cystic fibrosis lung
infection and ventilator-associated pneumonia is mediated both by pathogen virulence factors …

[HTML][HTML] Dysregulation of exosome cargo by mutant tau expressed in human-induced pluripotent stem cell (iPSC) neurons revealed by proteomics analyses

…, L Ransom, J Ames, G Shen, CB Lietz, Z Jiang… - Molecular & Cellular …, 2020 - ASBMB
Accumulation and propagation of hyperphosphorylated Tau (p-Tau) is a common
neuropathological hallmark associated with neurodegeneration of Alzheimer's disease (AD), …

Differential neuropeptidomes of dense core secretory vesicles (DCSV) produced at intravesicular and extracellular pH conditions by proteolytic processing

Z Jiang, CB Lietz, S Podvin, MC Yoon… - ACS chemical …, 2021 - ACS Publications
Neuropeptides mediate cell–cell signaling in the nervous and endocrine systems. The
neuropeptidome is the spectrum of peptides generated from precursors by proteolysis within …

[HTML][HTML] Quantitative multiplex substrate profiling of peptidases by mass spectrometry

JD Lapek, Z Jiang, JM Wozniak, E Arutyunova… - Molecular & Cellular …, 2019 - ASBMB
Proteolysis is an integral component of life and has been implicated in many disease processes.
To improve our understanding of peptidase function, it is imperative to develop tools to …

[HTML][HTML] SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties

…, P Fajtová, M Chanová, Z Jiang… - PLoS neglected …, 2018 - journals.plos.org
Background Serine proteases are important virulence factors for many pathogens. Recently,
we discovered a group of trypsin-like serine proteases with domain organization unique to …

The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni

…, SC Wang, J Almaliti, AP Ta, Z Jiang… - ACS infectious …, 2019 - ACS Publications
Proteases are fundamental to successful parasitism, including that of the schistosome flatworm
parasite, which causes the disease schistosomiasis in 200 million people worldwide. The …