Spatial genome organization and its effect on transcription remains a fundamental question.
We applied an advanced chromatin interaction analysis by paired-end tag sequencing (ChIA…

Oranges are an important nutritional source for human health and have immense economic
value. Here we present a comprehensive analysis of the draft genome of sweet orange (…

Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian
genomes. However, extrusion has not been visualized in vivo, and thus, its functional …

Blocking PD-1/PD-L1 signaling transforms cancer therapy and is assumed to unleash
exhausted tumor-reactive CD8 + T cells in the tumor microenvironment (TME). However, recent …

Enhancers regulate spatiotemporal gene expression and impart cell-specific transcriptional
outputs that drive cell identity 1 . Super-enhancers (SEs), also known as stretch-enhancers, …

A key finding of the ENCODE project is that the enhancer landscape of mammalian cells
undergoes marked alterations during ontogeny. However, the nature and extent of these …

The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously
damages oncogenes, leading to chromosomal translocations and tumorigenesis. Why …

Gossypium hirsutum contributes the most production of cotton fibre, but G. barbadense is
valued for its better comprehensive resistance and superior fibre properties. However, the …

The male sterility of thermosensitive genic male sterile ( TGMS ) lines of wheat (Triticum
aestivum) is strictly controlled by temperature. The early phase of anther development is …

The tandem duplicator phenotype (TDP) is a genome-wide instability configuration primarily
observed in breast, ovarian, and endometrial carcinomas. Here, we stratify TDP tumors by …