DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view of …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, …

Copy number variation (CNV) is a prevalent form of critical genetic variation that leads to an
abnormal number of copies of large genomic regions in a cell. Microarray-based …

… In the version of this article initially published, the name of author Zhongming Zhao was
misspelled Zhaoming Zhao. The error has been corrected in the HTML and PDF versions of the …

Hdac3 is essential for efficient DNA replication and DNA damage control. Deletion of Hdac3
impaired DNA repair and greatly reduced chromatin compaction and heterochromatin …

Reinvigoration of antitumor immunity remains an unmet challenge. Our retrospective analyses
revealed that cancer patients who took antihistamines during immunotherapy treatment …

Tumor suppressor genes (TSGs) are a major type of gatekeeper genes in the cell growth. A
knowledgebase with the systematic collection and curation of TSGs in multiple cancer types …

Tumor suppressor genes (TSGs) are guardian genes that play important roles in controlling
cell proliferation processes such as cell-cycle checkpoints and inducing apoptosis. …

Motivation: An important question that has emerged from the recent success of genome-wide
association studies (GWAS) is how to detect genetic signals beyond single markers/genes …

Objective Drug–drug interactions (DDIs) are an important consideration in both drug
development and clinical application, especially for co-administered medications. While it is …