User profiles for Zhongqi Liufu
 | Zhongqi Liufu生物岛实验室 Verified email at mail.sysu.edu.cn Cited by 133 |
Redundant and incoherent regulations of multiple phenotypes suggest microRNAs' role in stability control
Each microRNA (miRNA) represses a web of target genes and, through them, controls multiple
phenotypes. The difficulties inherent in such controls cast doubt on how effective miRNAs …
phenotypes. The difficulties inherent in such controls cast doubt on how effective miRNAs …
[PDF][PDF] Species-specific rewiring of definitive endoderm developmental gene activation via endogenous retroviruses through TET1-mediated demethylation
Transposable elements (TEs) are the major sources of lineage-specific genomic innovation
and comprise nearly half of the human genome, but most of their functions remain unclear. …
and comprise nearly half of the human genome, but most of their functions remain unclear. …
Canalization of phenotypes—when the transcriptome is constantly but weakly perturbed
Recent studies have increasingly pointed to microRNAs (miRNAs) as the agent of gene
regulatory network (GRN) stabilization as well as developmental canalization against constant …
regulatory network (GRN) stabilization as well as developmental canalization against constant …
[HTML][HTML] Small RNA transcriptomes of mangroves evolve adaptively in extreme environments
MicroRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) are key players in
plant stress responses. Here, we present the sRNA transcriptomes of mangroves Bruguiera …
plant stress responses. Here, we present the sRNA transcriptomes of mangroves Bruguiera …
Run or die in the evolution of new microRNAs—testing the Red Queen Hypothesis on de novo new genes
The Red Queen hypothesis depicts evolution as the continual struggle to adapt. According
to this hypothesis, new genes, especially those originating from nongenic sequences (ie, de …
to this hypothesis, new genes, especially those originating from nongenic sequences (ie, de …
Regulation of Large Number of Weak Targets—New Insights from Twin-microRNAs
Each animal microRNA (miRNA) targets many genes for repression. Down-regulation of most
of these targets is weak and has no detectable individual phenotypic effect. Whether this …
of these targets is weak and has no detectable individual phenotypic effect. Whether this …
Death of new microRNA genes in Drosophila via gradual loss of fitness advantages
The prevalence of de novo coding genes is controversial due to length and coding constraints.
Noncoding genes, especially small ones, are freer to evolve de novo by comparison. The …
Noncoding genes, especially small ones, are freer to evolve de novo by comparison. The …
[HTML][HTML] On the possibility of death of new genes–evidence from the deletion of de novo microRNAs
Background New genes are constantly formed, sometimes from non-genic sequences, creating
what is referred to as de novo genes. Since the total number of genes remains relatively …
what is referred to as de novo genes. Since the total number of genes remains relatively …
[HTML][HTML] Rapid evolution of autosomal binding sites of the dosage compensation complex in Drosophila melanogaster and its association with transcription divergence
A Dai, Y Wang, A Greenberg, Z Liufu, T Tang - Frontiers in Genetics, 2021 - frontiersin.org
How pleiotropy influences evolution of protein sequence remains unclear. The male-specific
lethal (MSL) complex in Drosophila mediates dosage compensation by 2-fold upregulation …
lethal (MSL) complex in Drosophila mediates dosage compensation by 2-fold upregulation …
[HTML][HTML] A Rapid Evolving microRNA Cluster Rewires Its Target Regulatory Networks in Drosophila
New miRNAs are evolutionarily important but their functional evolution remains unclear.
Here we report that the evolution of a microRNA cluster, mir-972C rewires its downstream …
Here we report that the evolution of a microRNA cluster, mir-972C rewires its downstream …