Down syndrome (DS) is caused by the presence of an extra copy of human chromosome 21
(Hsa21) and is the most common genetic cause for developmental cognitive disability. The …

The human homologue of the yeast OGG1 gene, hOGG1, has been cloned, and its genetic
structure has been determined. Several polymorphisms in the hOGG1 gene were detected in …

Down syndrome is caused by a genomic imbalance of human chromosome 21 which is
mainly observed as trisomy 21. The regions on human chromosome 21 are syntenically …

LGI1 in humans is responsible for a predisposition to autosomal dominant partial epilepsy
with auditory features (ADPEAF). However, mechanisms of how LGI1 mutations cause …

Pseudomonas aeruginosa is an opportunistic pathogen that forms antibiotic-resistant
biofilms, which facilitate chronic infections in immunocompromised hosts. We have previously …

In eukaryotic organisms, transfer RNA (tRNA)-derived fragments have diverse biological
functions. Considering the conserved sequences of tRNAs, it is not surprising that endogenous …

p53 ( TP53 ) is the most frequently mutated gene in squamous cell carcinomas ( SCCs ) of
the skin and head and neck. Certain p53 mutations are oncogenic and promote invasion and …

Background Whole-exome sequencing has shown that lung adenocarcinoma (LAC) can be
driven by mutant genes, including TP53, P16, and Smad4. The aim of this study was to …

Nonsense-mediated mRNA decay (NMD) is a network of pathways that degrades transcripts
that undergo premature translation termination. In mammals, NMD can be divided into the …

Objective The role of sauna bathing in cardiovascular function treatment has been increasingly
explored, but insufficient attention has been paid to its efficacy. We performed a meta-…