CRISPR–Cas9 screens have been widely adopted to analyze coding-gene functions, but
high-throughput screening of non-coding elements using this method is more challenging …

Current tools for targeted RNA editing rely on the delivery of exogenous proteins or chemically
modified guide RNAs, which may lead to aberrant effector activity, delivery barrier or …

The functions of many long noncoding RNAs (lncRNAs) in the human genome remain unknown
owing to the lack of scalable loss-of-function screening tools. We previously used pairs …

Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting
infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing …

Canonical CRISPR–knockout (KO) screens rely on Cas9-induced DNA double-strand breaks
(DSBs) to generate targeted gene KOs. These methodologies may yield distorted results …

We report a new method using re-designed guide RNAs with internal barcodes (iBARs)
embedded in their loop regions. Our iBAR approach outperforms the conventional method by …

Human pose estimation in images is challenging and important for many computer vision
applications. Large improvements in human pose estimation have been achieved with the …

In open-resource environments, unmanned aerial vehicle (UAV) swarms typically dynamically
supplement and replace UAVs in the event of mission loss. During this process, there is a …

Compositional models are meant for human pose estimation (HPE) due to their abilities to
capture relationships among human body parts. Deeply learned compositional model (DLCM) …

Colorectal cancer (CRC), a common malignant tumor, is one of the main causes of death in
cancer patients in the world. Therefore, it is critical to understand the molecular mechanism …