Population aging is a public health problem affecting the majority of the developed world. As
populations age, the incidence of degenerative diseases increases exponentially, leading …

Disruption of mitochondrial metabolism and loss of mitochondrial DNA (mtDNA) integrity are
widely considered as evolutionarily conserved (public) mechanisms of aging (López‐Otín et …

Aging animals accumulate insoluble proteins as a consequence of a decline of proteostatic
maintenance with age. In Caenorhabditis elegans, for instance, levels of detergent-insoluble …

Protein turnover maintains the proteome’s functional integrity. Here, protein turnover
efficiency over time in wild-type Caenorhabditis elegans was assessed using inverse [ 15 N]-pulse …

Broad evidence support double-strand breaks (DSBs) as initiators of mitochondrial DNA (mtDNA)
deletion mutations. But the mechanism of DSB-induced deletions, including the DSB …

Broad evidence in the literature supports double-strand breaks (DSBs) as initiators of
mitochondrial DNA (mtDNA) deletion mutations. While DNA misalignment during DSB repair is …

One fundamental cause of ageing often considered is the accumulation of different kinds of
macromolecular damage. Damage accumulation theories suggest a causal link between …

The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …

Eukaryotic cells respond to DNA damage and stalled replication forks by activating signaling
pathways that promote cell cycle arrest and DNA repair. A systematic screening of the …

Polycomb-repressive complex 2 (PRC2)-mediated histone methylation plays an important
role in aberrant cancer gene silencing and is a potential target for cancer therapy. Here we …