Wnt regulation of β-catenin degradation is essential for development and carcinogenesis. β-catenin
degradation is initiated upon amino-terminal serine/threonine phosphorylation, …

† These authors contributed equally to this work. § e-mail: Yankner@ A1. tch. harvard. edu
utations in presenilin-1 (PS1) and presenilin-2 (PS2) cause early-onset familial Alzheimer’s …

Mutations of the presenilin-1 gene are a major cause of familial early-onset Alzheimer's
disease 1 , 2 , 3 , 4 . Presenilin-1 can associate with members of the catenin family of signalling …

Amyloid β protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The
fibrillar form of Aβ is neurotoxic, although the mechanism of its toxicity is unknown. We …

Many hereditary and sporadic neurodegenerative disorders are characterized by the
accumulation of aberrant proteins. In sporadic Parkinson's disease, representing the most …

Mutations in PARKIN, pten-induced putative kinase 1 (PINK1), and DJ-1 are individually
linked to autosomal recessive early-onset familial forms of Parkinson disease (PD). Although …

Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease (AD).
Amyloid β-protein (Aβ), the central component of neuritic plaques, is derived from β-…

Regulation of β-catenin stability is essential for Wnt signal transduction during development
and tumorigenesis. It is well known that serine-phosphorylation of β-catenin by the Axin–…

Expression of a constitutively active R-ras converted two cell lines that grow in suspension
into highly adherent cells. There was little change in cell surface expression of integrins, but …

FIBRONECTIN is an extracellular matrix protein that is important in development, wound
healing and tumorigenesis 1–5 . In the blood it is dimeric, but in tissues forms disulphide …