Glycine N‐methyltransferase (GNMT) is the main enzyme responsible for catabolism of
excess hepatic S‐adenosylmethionine (SAMe). GNMT is absent in hepatocellular carcinoma (…

Methylation is a major biological process. It has been shown to be important in formation of
compounds such as phosphatidylcholine, creatine, and many others and also participates in …

Because plants are sessile, they have developed intricate strategies to adapt to changing
environmental variables, including light. Their growth and development, from germination to …

Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
in most western countries. Current NAFLD diagnosis methods (eg, liver biopsy analysis or …

This paper reports clinical and metabolic studies of two Italian siblings with a novel form of
persistent isolated hypermethioninaemia, ie abnormally elevated plasma methionine that …

Purpose: There is a compelling clinical imperative to identify discerning molecular biomarkers
of hepatic disease in order to inform the diagnosis, prognosis and treatment. Experimental …

BACKGROUND & AIMS: Hepatic de-differentiation, liver development, and malignant
transformation are processes in which the levels of hepatic S-adenosylmethionine are tightly …

Methionine adenosyltransferase 1A (MAT1A) and glycine N‐methyltransferase (GNMT) are
the primary genes involved in hepatic S‐adenosylmethionine (SAMe) synthesis and …

Three human cases having mutations in the glycine N-methyltransferase (GNMT) gene have
been reported. This enzyme transfers a methyl group from S-adenosylmethionine (SAM) to …

Background Clinical decision for primary treatment for prostate cancer is dictated by
variables with insufficient specificity. Early detection of prostate cancer likely to develop rapid …