A critical role of the amyloid precursor protein (APP) in Alzheimer's disease (AD) pathogenesis
has been well established. However, the physiological function of APP remains elusive …

We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-proliferative
therapies. Functional characterization of spontaneous glioblastomas from …

A central question in glioblastoma multiforme (GBM) research is the identity of the tumor-initiating
cell, and its contribution to the malignant phenotype and genomic state. We examine …

Cancer-specific inhibitors that reflect the unique metabolic needs of cancer cells are rare.
Here we describe Gboxin, a small molecule that specifically inhibits the growth of primary …

The contribution of lineage identity and differentiation state to malignant transformation is
controversial. We have previously shown that adult neural stem and early progenitor cells give …

Glioblastoma, the predominant adult malignant brain tumor, has been computationally
classified into molecular subtypes whose functional relevance remains to be comprehensively …

Impaired neurogenesis in the adult hippocampus has been implicated in AD pathogenesis.
Here we reveal that the APP plays an important role in the neural progenitor proliferation and …

Adult neurogenesis persists in the rodent dentate gyrus and is stimulated by chronic treatment
with conventional antidepressants through BDNF/TrkB signaling. Ketamine in low doses …

Amyloidogenic processing of the amyloid precursor protein (APP) generates a large secreted
ectodomain fragment (APPsβ), β-amyloid (Aβ) peptides, and an APP intracellular domain (…

Amyloid precursor protein (APP) has been strongly implicated in the pathogenesis of
Alzheimer's disease (AD). Although impaired synaptic function is believed to be an early and …