[HTML][HTML] SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

…, X Pan, FL Liu, Y Wang, F Yang, S Fang, Y Wu, Z Duan… - Cell research, 2021 - nature.com
Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.
However, the origin of excessive damages caused by SARS-CoV-2 remains largely unknown. …

Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system

P Wang, L Jin, M Zhang, Y Wu, Z Duan, Y Guo… - Nature Biomedical …, 2023 - nature.com
In some patients, COVID-19 can trigger neurological symptoms with unclear pathogenesis.
Here we describe a microphysiological system integrating alveolus and blood–brain barrier (…

Transferrin receptor is another receptor for SARS-CoV-2 entry

X Tang, M Yang, Z Duan, Z Liao, L Liu, R Cheng… - BioRxiv, 2020 - biorxiv.org
Angiotensin-converting enzyme 2 (ACE2) has been suggested as a receptor for severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry to cause coronavirus disease …

A short peptide from frog skin accelerates diabetic wound healing

H Liu, Z Duan, J Tang, Q Lv, M Rong, R Lai - The FEBS journal, 2014 - Wiley Online Library
Delayed wound healing will result in the development of chronic wounds in some diseases,
such as diabetes. Amphibian skins possess excellent wound‐healing ability and represent a …

[HTML][HTML] Role of LL-37 in thrombotic complications in patients with COVID-19

Z Duan, J Zhang, X Chen, M Liu, H Zhao, L Jin… - Cellular and Molecular …, 2022 - Springer
Blood clot formation induced by dysfunctional coagulation is a frequent complication of
coronavirus disease 2019 (COVID-19) and a high-risk factor for severe illness and death. …

The 14-3-3ζ–c-Src–integrin-β3 complex is vital for platelet activation

…, P Chen, W Ma, J Mwangi, Q Lu, Z Duan… - Blood, The Journal …, 2020 - ashpublications.org
Several adaptor molecules bind to cytoplasmic tails of β-integrins and facilitate bidirectional
signaling, which is critical in thrombosis and hemostasis. Interfering with integrin-adaptor …

Human antimicrobial peptide LL-37 contributes to Alzheimer's disease progression

X Chen, S Deng, W Wang, S Castiglione, Z Duan… - Molecular …, 2022 - nature.com
As a prime mover in Alzheimer’s disease (AD), microglial activation requires membrane
translocation, integration, and activation of the metamorphic protein chloride intracellular …

[HTML][HTML] A small peptide with therapeutic potential for inflammatory acne vulgaris

Z Zhang, L Mu, J Tang, Z Duan, F Wang, L Wei… - PLoS …, 2013 - journals.plos.org
A designed peptide named LZ1 with 15 amino acid residues containing strong antimicrobial
activity against bacteria pathogens of acne vulgaris including Propionibacterium acnes , …

Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation

FL Liu, K Wu, J Sun, Z Duan, X Quan… - National Science …, 2021 - academic.oup.com
About every 26 months, the distance between Earth and Mars reaches a minimum, and that
is the best time window for Mars exploration from Earth. In July 2020, three spacecraft started …

Human transferrin receptor can mediate SARS-CoV-2 infection

…, C Wang, X Tang, M Yang, Z Duan… - Proceedings of the …, 2024 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been detected
in almost all organs of coronavirus disease-19 patients, although some organs do not …