Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

…, JP Tosar, Z Useckaite… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

[HTML][HTML] Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancer pathogenesis: A spotlight on the contribution of the endosome-lysosome …

J Tang, GT Lam, RD Brooks, M Miles, Z Useckaite… - Cancer Letters, 2024 - Elsevier
The highly heterogenous nature of colorectal cancer can significantly hinder its early and
accurate diagnosis, eventually contributing to high mortality rates. The adenoma-carcinoma …

Role of extracellular vesicle-derived biomarkers in drug metabolism and disposition

Z Useckaite, AD Rodrigues, AM Hopkins… - Drug Metabolism and …, 2021 - ASPET
Extracellular vesicles (EVs) are small, nonreplicating, lipid-encapsulated particles that contain
a myriad of protein and nucleic acid cargo derived from their tissue of origin. The potential …

Exploring the use of serum‐derived small extracellular vesicles as liquid biopsy to study the induction of hepatic cytochromes P450 and organic anion transporting …

…, MJ Sorich, A Fahmy, Z Useckaite… - Clinical …, 2021 - Wiley Online Library
Liver‐derived small extracellular vesicles (sEVs), prepared from small sets of banked serum
samples using a novel two‐step protocol, were deployed as liquid biopsy to study the …

[HTML][HTML] Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo

MC Cathcart, Z Useckaite, C Drakeford, V Semik… - BMC cancer, 2016 - Springer
Background Baicalein is a widely used Chinese herbal medicine derived from Scutellaria
baicalenesis, which has been traditionally used as anti-inflammatory and anti-cancer therapy. …

[HTML][HTML] Selective isolation of liver-derived extracellular vesicles redefines performance of miRNA biomarkers for non-alcoholic fatty liver disease

LA Newman, Z Useckaite, J Johnson, MJ Sorich… - Biomedicines, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Definitive
diagnosis of the progressive form, non-alcoholic steatohepatitis (NASH), requires liver …

[HTML][HTML] Importance of between and within subject variability in extracellular vesicle abundance and cargo when performing biomarker analyses

…, MJ Sorich, OG Best, A Rowland, Z Useckaite - Cells, 2021 - mdpi.com
Small extracellular vesicles (sEV) have emerged as a potential rich source of biomarkers in
human blood and present the intriguing potential for a ‘liquid biopsy’ to track disease and the …

Optimisation and comparison of orthogonal methods for separation and characterisation of extracellular vesicles to investigate how representative infant milk formula …

A Mukhopadhya, J Santoro, B Moran, Z Useckaite… - Food Chemistry, 2021 - Elsevier
Many infants are fed infant milk formula (IMF). However, IMF production from skim milk (SM)
involves harsh treatment. So, we hypothesised that the quantity and/or quality of …

The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function

…, SL Doyle, S Channon, Z Useckaite… - Journal of Leucocyte …, 2016 - academic.oup.com
The role of NK cells in visceral adipose tissue (VAT) and liver inflammation in obesity is not
fully understood. This study investigated the frequency, cytokine expression, chemokine …

Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis

Z Useckaite, MP Ward, A Trappe, R Reilly, J Lennon… - Thorax, 2020 - thorax.bmj.com
Rationale Mutations in the cystic fibrosis transmembrane regulator (CFTR) gene form the
basis of cystic fibrosis (CF). There remains an important knowledge gap in CF as to how …