The VP40 protein of Ebola virus can bud from mammalian cells in the form of lipid-bound,
virus-like particles (VLPs), and late budding domains (L-domains) are conserved motifs (PTAP, …

The VP40 matrix protein of Ebola virus buds from cells in the form of virus-like particles (VLPs)
and plays a central role in virus assembly and budding. In this study, we utilized a …

Background Acute necrotizing pancreatitis (NP), a severe form of acute pancreatitis (AP),
has higher mortality and worse outcome than non-necrotizing pancreatitis (non-NP). Infected …

The VP24 protein of Ebola virus is believed to be a secondary matrix protein and minor
component of virions. In contrast, the VP40 protein of Ebola virus is the primary matrix protein …

In the sera of patients infected with hepatitis B virus (HBV), in addition to infectious particles,
there is an excess (typically 1,000- to 100,000-fold) of empty subviral particles (SVP) …

Previous studies have indicated that the replication of the RNA genome of hepatitis delta virus
(HDV) involves redirection of RNA polymerase II (Pol II), a host enzyme that normally uses …

Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host
proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains …

Antiviral compounds that increase the resistance of host tissues represent an attractive class
of therapeutic. Here, we show that squalamine, a compound previously isolated from the …

Viroporins compose a group of small hydrophobic transmembrane proteins that can form
hydrophilic pores through lipid bilayers. Viroporins have been implicated in promoting virus …

The tumor microenvironment (TME) plays a central role in tumor initiation, development,
immune escape, and clinical treatment. Hypoxia, an important characteristic of the TME, …