Transcription is a multistep, tightly regulated process. During transcription initiation, promoter
recognition and pre-initiation complex (PIC) formation take place, in which dynamic …

Breast cancer is the most frequent cancer with a high fatality rate amongst women worldwide.
Diagnosing at an early stage is challenging, and due to the limitations of the currently used …

Introduction: Adipose tissue-derived mesenchymal stem cells are promising contributors to
regenerative medicine, exhibiting the ability to regenerate tissues and modulate the immune …

DNA repair pathways trigger robust downstream responses, making it challenging to select
suitable reference genes for comparative studies. In this study, our goal was to identify the …

DNA double-strand breaks are one of the most deleterious lesions for the cells, therefore
understanding the macromolecular interactions of the DNA repair-related mechanisms is …

UV-induced DNA damage response and repair are extensively studied processes, as any
malfunction in these pathways contributes to the activation of tumorigenesis. Although several …

Ubiquitylation is critical for preventing aberrant DNA repair and for efficient maintenance of
genome stability. As deubiquitylases (DUBs) counteract ubiquitylation, they must have a …

… G and H. Wild-type and not5Δ cells expressing Rpb4-TT (G) or the indicated (H) Not5
derivatives, were grown exponentially and stained with anti-CBP antibodies (upper panels) or …

DNA double-strand breaks are the most deleterious lesions for the cells, therefore understanding
the macromolecular interactions in the DNA repair-related mechanisms is essential. …

The molting during Drosophila development is tightly regulated by the ecdysone hormone.
Several steps of the ecdysone biosynthesis have been already identified but the regulation of …